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Seasonal temperature is associated with Parkinson’s disease prescriptions: an ecological study

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Abstract

The aim of this study is to test what effect the weather may have on medications prescribed to treat Parkinson’s disease. Twenty-three years of monthly time, series data was sourced from the Pharmaceutical Benefits Scheme (PBS) and the Bureau of Meteorology (BOM). Data were available for eight states and territories and their corresponding capital cities. The dependent variable was the aggregate levodopa equivalent dose (LED) for 51 Parkinson’s medications identified on the PBS. Two explanatory variables of interest, temperature and solar exposure, were identified in the BOM data set. Linear and cosinor models were estimated with fixed and random effects, respectively. The prescribed LED was 4.2% greater in January and 4.5% lower in July. Statistical analysis showed that temperature was associated with the prescription of Parkinson medications. Our results suggest seasonality exists in Parkinson’s disease symptoms and this may be related to temperature. Further work is needed to confirm these findings and understand the underlying mechanisms as a better understanding of the causes of any seasonal variation in Parkinson’s disease may help clinicians and patients manage the disease more effectively.

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Notes

  1. The monthly change in the LED is estimated by: \( \varDelta LED\%=\frac{\left({\overline{w}}_m-\overline{w}\right)\times 100}{\overline{w}}\times {\alpha}_2 \)

    \( {\overline{w}}_m \) = Weighted monthly mean temperature

    \( \overline{w} \) = Weighted annual mean temperature

    α 2 = 0.18 (see Table 2)

References

  • Anca M, Paleacu D, Shabtai H, Giladi N (2002) Cross-sectional study of the prevalence of Parkinson’s disease in the kibbutz movement in Israel. Neuroepidemiology 21:50–55

    Article  CAS  Google Scholar 

  • Australian Bureau of Statistics (2008) Year book Australia 2008 ABS Catalogue No. 1301.0. ABS, Canberra

  • Barnett AG, Dobson AJ (2010) Analysing seasonal health data, vol 30. Springer

  • Betemps EJ, Buncher RC (1993) Birthplace as a risk factor in motor neurone disease and Parkinson’s disease. Int J Epidemiol 22(5):898–904

    Article  CAS  Google Scholar 

  • Bureau of Meteorology (2016) Climate data online. Commonwealth of Australia http://www.bom.gov.au/climate/data/?ref=ftr. Accessed June 2015

  • Deloitte Access Economics (2015) Living with Parkinson’s Disease: An updated economic analysis 2014. Report prepared for Parkinson’s Australia. Deloitte

  • Ding H, Dhima K, Lockhart KC, Locascio JJ, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Hayes MT, Sohur US, Wills A-M (2013) Unrecognized vitamin D3 deficiency is common in Parkinson disease Harvard biomarker study. Neurology 81(17):1531–1537

    Article  CAS  Google Scholar 

  • Donnelly N, McManus P, Dudley J, Hall W (2000) Impact of increasing the re-supply interval on the seasonality of subsidised prescription use in Australia. Aust N Z J Public Health 24(6):603–606

    Article  CAS  Google Scholar 

  • Eisen A, Calne D (1992) Amyotrophic lateral sclerosis, Parkinson’s disease and Alzheimer’s disease: phylogenetic disorders of the human neocortex sharing many characteristics. Can J Neurol Sci/Journal Canadien des Sciences Neurologiques 19(S1):117–123

    CAS  Google Scholar 

  • Eisenberg DP, Kohn PD, Baller EB, Bronstein JA, Masdeu JC, Berman KF (2010) Seasonal effects on human striatal presynaptic dopamine synthesis. J Neurosci 30(44):14691–14694

    Article  CAS  Google Scholar 

  • Gardener H, Gao X, Chen H, Schwarzschild MA, Spiegelman D, Ascherio A (2010) Prenatal and early life factors and risk of Parkinson’s disease. Mov Disord 25(11):1560–1567

    Article  Google Scholar 

  • Goetz CG, Li JM, Wuu J, Leurgans S (2006) Does seasonal variation affect hallucinations in PD? A longitudinal study. Mov Disord 21(6):863–865

    Article  Google Scholar 

  • Guatteo E, Chung KK, Bowala TK, Bernardi G, Mercuri NB, Lipski J (2005) Temperature sensitivity of dopaminergic neurons of the substantia nigra pars compacta: involvement of transient receptor potential channels. J Neurophysiol 94(5):3069–3080

    Article  CAS  Google Scholar 

  • Hynd A, Roughead EE, Preen DB, Glover J, Bulsara M, Semmens J (2008) The impact of co-payment increases on dispensings of government-subsidised medicines in Australia. Pharmacoepidemiol Drug Saf 17(11):1091–1099

    Article  Google Scholar 

  • Kaasinen V, Jokinen P, Joutsa J, Eskola O, Rinne JO (2012) Seasonality of striatal dopamine synthesis capacity in Parkinson’s disease. Neurosci Lett 530(1):80–84

    Article  CAS  Google Scholar 

  • Karson CN, Berman KF, Kleinman J, Karoum F (1984) Seasonal variation in human central dopamine activity. Psychiatry Res 11(2):111–117

    Article  CAS  Google Scholar 

  • Kiyatkin EA (2010) Brain temperature homeostasis: physiological fluctuations and pathological shifts. Front Biosci 15:73

    Article  CAS  Google Scholar 

  • Knekt P, Kilkkinen A, Rissanen H, Marniemi J, Sääksjärvi K, Heliövaara M (2010) Serum vitamin D and the risk of Parkinson disease. Arch Neurol 67(7):808–811

    Article  Google Scholar 

  • Mattock C, Marmot M, Stern G (1988) Could Parkinson’s disease follow intra-uterine influenza?: a speculative hypothesis. J Neurol Neurosurg Psychiatry 51(6):753–756

    Article  CAS  Google Scholar 

  • Meigal A, Lupandin Y (2005) “Thermoregulation-dependent component” in pathophysiology of motor disorders in Parkinson's disease? Pathophysiology 11(4):187–196

    Article  CAS  Google Scholar 

  • Miura T, Shimura M, Kimura T (1987) Season of birth in parkinsonism. Prog Biometeorol 6:157–162

    Google Scholar 

  • Nair R, Maseeh A (2012) Vitamin D: the “sunshine” vitamin. J Pharmacol Pharmacother 3(2):118

    CAS  Google Scholar 

  • Newmark HL, Newmark J (2007) Vitamin D and Parkinson’s disease—a hypothesis. Mov Disord 22(4):461–468

    Article  Google Scholar 

  • Palladino R, Moccia M, De Pascale T, Montella E, Torre I, Vitale C, Barone P, Triassi M (2015) Season of birth and Parkinson’s disease: possible relationship? Neurol Sci 36(8):1457–1462

    Article  Google Scholar 

  • Peterson AL, Mancini M, Horak FB (2013) The relationship between balance control and vitamin D in Parkinson’s disease—a pilot study. Mov Disord 28(8):1133–1137

    Article  Google Scholar 

  • Pittaway JK, Ahuja KD, Beckett JM, Bird M-L, Robertson IK, Ball MJ (2013) Make vitamin D while the sun shines, take supplements when it doesn’t: a longitudinal, observational study of older adults in Tasmania, Australia. PLoS One 8(3):e59063

    Article  CAS  Google Scholar 

  • Postuma RB, Arenovich T, Lang AE (2005) Does severity of Parkinson’s disease vary according to season? Mov Disord 20(4):476–479

    Article  Google Scholar 

  • Postuma RB, Wolfson C, Rajput A, Stoessl AJ, Martin W, Suchowersky O, Chouinard S, Panisset M, Jog MS, Grimes DA (2007) Is there seasonal variation in risk of Parkinson’s disease? Mov Disord 22(8):1097–1101

    Article  Google Scholar 

  • Rango M, Arighi A, Bonifati C, Bresolin N (2012) Increased brain temperature in Parkinson’s disease. Neuroreport 23(3):129–133

    Article  Google Scholar 

  • Rohn TT, Catlin LW (2011) Immunolocalization of influenza A virus and markers of inflammation in the human Parkinson’s disease brain. PLoS One 6(5):e20495

    Article  CAS  Google Scholar 

  • Sato Y, Kikuyama M, Oizumi K (1997) High prevalence of vitamin D deficiency and reduced bone mass in Parkinson’s disease. Neurology 49(5):1273–1278

    Article  CAS  Google Scholar 

  • Suzuki M, Yoshioka M, Hashimoto M, Murakami M, Kawasaki K, Noya M, Takahashi D, Urashima M (2012) 25-hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson’s disease. Mov Disord 27(2):264–271

    Article  CAS  Google Scholar 

  • Suzuki M, Yoshioka M, Hashimoto M, Murakami M, Noya M, Takahashi D, Urashima M (2013) Randomized, double-blind, placebo-controlled trial of vitamin D supplementation in Parkinson disease. Am J Clin Nutr 97(5):1004–1013

    Article  CAS  Google Scholar 

  • Svenson L (1991) Regional disparities in the annual prevalence rates of Parkinson’s disease in Canada. Neuroepidemiology 10(4):205–210

    Article  CAS  Google Scholar 

  • Tomlinson CL, Stowe R, Patel S, Rick C, Gray R, Clarke CE (2010) Systematic review of levodopa dose equivalency reporting in Parkinson’s disease. Mov Disord 25(15):2649–2653. https://doi.org/10.1002/Mds.23429

  • Toovey S, Jick SS, Meier CR (2011) Parkinson’s disease or Parkinson symptoms following seasonal influenza. Influenza Other Respir Viruses 5(5):328–333

    Article  Google Scholar 

  • van Gool K, Parkinson B, Kenny P (2011) Medicare Australia data for research: an introduction Centre for Health Economics Research and Evaluation (CHERE), Sydney

  • Wang YS, Shi YM, Wu ZY, He YX, Zhang BZ (1991) Parkinson’s disease in China. Coordinational Group of Neuroepidemiology, PLA. Chin Med J 104(11):960–964

    CAS  Google Scholar 

  • Wooldridge JM (2000) Introductory econometrics: a modern approach. Southern-Western College Publishing, USA

    Google Scholar 

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Acknowledgements

We would like to thank Dr. Douglas Rowell for his assistance with interpreting the meteorological data.

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No external funding was provided for this research.

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Correspondence to David Rowell.

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Rowell, D., Nghiem, S., Ramagopalan, S. et al. Seasonal temperature is associated with Parkinson’s disease prescriptions: an ecological study. Int J Biometeorol 61, 2205–2211 (2017). https://doi.org/10.1007/s00484-017-1427-9

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  • DOI: https://doi.org/10.1007/s00484-017-1427-9

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