Nephrotic range proteinuria in an adolescent with a diagnosis of Wilson’s disease: Answers

This is a preview of subscription content, access via your institution.

Fig. 1

Data availability

Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.


  1. 1.

    Kitzberger R, Madl C, Ferenci P (2005) Wilson disease. Metab Brain Dis 20:295–302.

    Article  PubMed  Google Scholar 

  2. 2.

    Scheinberg IH (1984) Wilson’s disease. Major Probl Intern Med 23:9–16

    Google Scholar 

  3. 3.

    Zhuang XH, Mo Y, Jiang XY, Chen SM (2008) Analysis of renal impairment in children with Wilson’s disease. World J Pediatr 4:102–105.

    Article  PubMed  Google Scholar 

  4. 4.

    Helmy H, Fahmy M, Abdel Aziz H, Ghobrial C, Abdel Hameed N, El-Karaksy H (2019) Urinary abnormalities in children and adolescents with Wilson disease before and during treatment with d-penicillamine. J Gastroenterol Hepatol 34:1824–1828.

    CAS  Article  PubMed  Google Scholar 

  5. 5.

    Selvan C, Thukral A, Chakraborthy PP, Bhattacharya R, Roy A, Goswani S, Meher D, Ghosh S, Mukhopadhyay S, Chowdhury S (2012) Refractory rickets due to Fanconi’s syndrome secondary to Wilson’s disease. Indian J Endocrinol Metab 16(Suppl 2):S399

    PubMed  PubMed Central  Google Scholar 

  6. 6.

    Di Stefano V, Lionetti E, Rotolo N, La Rosa M, Leonardi S (2012) Hypercalciuria and nephrocalcinosis as early feature of Wilson disease onset: description of a pediatric case and literature review. Hepat Mon 12:e6233.

    Article  PubMed  PubMed Central  Google Scholar 

  7. 7.

    Tu J, Chen C, Li H, Chu M, Geng H (2017) A special case of recurrent gross hematuria: answers. Pediatr Nephrol 32:273–275.

    Article  PubMed  Google Scholar 

  8. 8.

    Shimamura Y, Maeda T, Gocho Y, Ogawa Y, Tsuji K, Takizawa H (2019) Immunoglobulin A nephropathy secondary to Wilson’s disease: a case report and literature review. CEN Case Rep 8:61–66.

    Article  PubMed  Google Scholar 

  9. 9.

    Gunduz Z, Dusunsel R, Anarat A (1996) Wilson cirrhosis associated with membranoproliferative glomerulonephritis. Nephron 74:497–498.

    CAS  Article  PubMed  Google Scholar 

  10. 10.

    Ul Abideen Z, Sajjad Z, Haroon Khan A, Mamoon N, Bilal M, Mujtaba Quadri KH (2016) Immunoglobulin M nephropathy in a patient with Wilson’s disease. Cureus 8:e929.

    Article  PubMed  PubMed Central  Google Scholar 

  11. 11.

    Zhang Y, Wang D, Wei W, Zeng X (2018) Wilson’s disease combined with systemic lupus erythematosus: a case report and literature review. BMC Neurol 18:85.

    Article  PubMed  PubMed Central  Google Scholar 

  12. 12.

    Pradhan S, Krishnamurthy S, Jagadisan B, Rajesh NG, Kaliaperumal S, Ramasamy S, Subramanian N (2019) Wilson disease and lupus nephritis: is it coincidence or a true association? Paediatr Int Child Health 39:146–149.

    Article  PubMed  Google Scholar 

  13. 13.

    Dell’era L, Boati E, Nebbia G, Corona F (2012) Wilson’s disease treated with penicillamine and lupus erythematosus: related or distinct entities? Minerva Pediatr 64:55–57

    PubMed  Google Scholar 

  14. 14.

    Strand S, Hofmann WJ, Grambihler A, Hug H, Volkmann M, Otto G, Wesch H, Mariani SM, Hack V, Stremmel W (1998) Hepatic failure and liver cell damage in acute Wilson’s disease involve CD95 (APO-1/Fas) mediated apoptosis. Nat Med 4:588–593

    CAS  Article  Google Scholar 

  15. 15.

    O’Reilly LA, Tai L, Lee L, Kruse EA, Grabow S, Fairlie WD, Haynes NM, Tarlinton DM, Zhang J-G, Belz GT (2009) Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature 461:659–663

    Article  Google Scholar 

  16. 16.

    Walshe J (1956) Wilson’s disease: new oral therapy. Lancet 267:25–26

    Article  Google Scholar 

  17. 17.

    Hall CL, Jawad S, Harrison PR, MacKenzie JC, Bacon PA, Klouda PT, MacIver AG (1988) Natural course of penicillamine nephropathy: a long term study of 33 patients. Br Med J (Clin Res Ed) 296:1083–1086.

    CAS  Article  Google Scholar 

  18. 18.

    Habib GS, Saliba W, Nashashibi M, Armali Z (2006) Penicillamine and nephrotic syndrome. Eur J Intern Med 17:343–348

    CAS  Article  Google Scholar 

  19. 19.

    Kang S, Cho MH, Hyun H, Kim JH, Ko JS, Kang HG, Cheong HI, Kim WS, Moon KC, Ha I-S (2019) A pediatric case of a D-penicillamine induced ANCA-associated vasculitis manifesting a pulmonary-renal syndrome. J Korean Med Sci 34:e173.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  20. 20.

    Lee Y, Lee ST, Cho H (2016) D-penicillamine-induced ANA (+) ANCA (+) vasculitis in pediatric patients with Wilson’s disease. Clin Nephrol 85:296–300.

    CAS  Article  PubMed  Google Scholar 

  21. 21.

    Menon S, Valentini RP (2010) Membranous nephropathy in children: clinical presentation and therapeutic approach. Pediatr Nephrol 25:1419–1428.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Code availability


Author information



Corresponding author

Correspondence to Ayşe Ağbaş.

Ethics declarations

Ethics approval and consent to participate

None. Oral permission of the parents and the children was obtained.

Consent for publication

The patient and her parents have consented to the submission of the case report to the journal.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This refers to the article that can be found at

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Ağbaş, A., Bay, E.D., Başaran, M.K. et al. Nephrotic range proteinuria in an adolescent with a diagnosis of Wilson’s disease: Answers. Pediatr Nephrol (2021).

Download citation


  • Wilson’s disease
  • Proteinuria
  • Penicillamine
  • Membranous glomerulopathy