Infectious disease risks in pediatric renal transplantation

Review
Part of the following topical collections:
  1. What’s New in Renal Transplantation

Abstract

Renal transplantation is a vital treatment option in children with ESRD with more than 10,000 pediatric kidney transplants and survival rates of greater than 80% at 10 years post-transplant in the USA alone. Despite these advances, infection remains a significant cause of morbidity in pediatric recipients. Screening potential organ donors and recipients is imperative to identify and mitigate infectious risks in the transplant patient. Despite the unique risks of each patient, the timing of many infections post-transplant is predictable. In early post-transplant infections (within 30 days), bacterial and fungal pathogens predominate with donor-derived events and nosocomial infections. In the intermediate period (31–180 days after transplant), latent infections from donor organs, such as EBV and CMV, develop. Late infections occurring > 180 days after the transplant can be due to latent pathogens or community-acquired organisms. Approaching an infectious evaluation in a pediatric kidney recipient requires finesse to diagnose and treat this vulnerable population in a timely manner. The following article highlights the most relevant and common infections including clinical manifestations, risk factors, diagnostic techniques, and treatment options.

Keywords

Pediatric infections Renal transplant Post-transplant infections Infection in immunocompromised child 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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© IPNA 2018

Authors and Affiliations

  1. 1.Department of Pediatrics, Division of Infectious DiseasesCincinnati Children’s Hospital Medical CenterCincinnatiUSA
  2. 2.Department of Pediatrics, Division of Infectious DiseasesCincinnati Children’s Hospital Medical CenterCincinnatiUSA

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