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An unusual case of membranous nephropathy associated with an ovarian tumor

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Abstract

Secondary membranous nephropathy (MN) associated with malignancy is not uncommon in adults, but it is rare in children. We report a 6-year-old girl who developed nephrotic-range proteinuria following diagnosis of a Sertoli–Leydig ovarian tumor. A renal biopsy was performed, which led to the diagnosis of MN. The patient maintained normal renal function and gradually showed improvement in proteinuria over several months without the use of corticosteroids or angiotensin-converting enzyme inhibitors. Our case highlights the importance of performing screening urinalyses in children with tumors to recognize the presence of clinically significant, but potentially asymptomatic kidney disease.

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References

  1. Ronco P, Debiec H (2010) Membranous glomerulopathy: the evolving story. Curr Opin Nephrol Hypertens 19:254–259

    Article  Google Scholar 

  2. Ponticelli C (2007) Membranous nephropathy. J Nephrol 20:268–287

    CAS  PubMed  Google Scholar 

  3. Cameron JS (1990) Membranous nephropathy in childhood and its treatment. Pediatr Nephrol 4:193–198

    Article  CAS  Google Scholar 

  4. Menon S, Valentini RP (2010) Membranous nephropathy in children: clinical presentation and therapeutic approach. Pediatr Nephrol 25:1419–1428

    Article  Google Scholar 

  5. Beauvais P, Vaudour G, Boccon-Gibod L, Levy M (1989) Membranous nephropathy associated with ovarian tumour in a young girl: recovery after removal. Eur J Pediatr 148:624–625

    Article  CAS  Google Scholar 

  6. Schwartz GJ, Brion LP, Spitzer A (1987) The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Pediatr Clin North Am 34:571–590

    Article  CAS  Google Scholar 

  7. Zheng HL, Maruyama T, Matsuda S, Satomura K (1979) Neuroblastoma presenting with the nephrotic syndrome. J Pediatr Surg 14:414–419

    Article  CAS  Google Scholar 

  8. Lefaucheur C, Stengel B, Nochy D, Martel P, Hill GS, Jacquot C, Rossert J (2006) Membranous nephropathy and cancer: epidemiologic evidence and determinants of high-risk cancer association. Kidney Int 70:1510–1517

    Article  CAS  Google Scholar 

  9. Bacchetta J, Juillard L, Cochat P, Drox J-P (2009) Paraneoplastic glomerular diseases and malignancies. Crit Rev Oncol Hematol 70:39–58

    Article  Google Scholar 

  10. Pascal RR, Slovin SF (1980) Tumor directed antibody and carcinoembryonic antigen in the glomeruli of a patient with gastric carcinoma. Hum Pathol 11:679–682

    Article  CAS  Google Scholar 

  11. Costanza ME, Pinn V, Schwartz RS, Nathanson L (1973) Carcinoembryonic antigen-antibody complexes in a patient with colonic carcinoma and nephrotic syndrome. N Engl J Med 289:520–522

    Article  CAS  Google Scholar 

  12. Olson JL, Philips TM, Lewis MG, Solez K (1979) Malignant melanoma with renal dense deposits containing tumor antigens. Clin Nephrol 12:74–82

    CAS  PubMed  Google Scholar 

  13. Couser WG, Wagonfeld JB, Spargo BH, Lewis EJ (1974) Glomerular deposition of tumor antigen in membranous nephropathy associated with colonic carcinoma. Am J Med 57:962–970

    Article  CAS  Google Scholar 

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  1. Ashton Chen

    Present address: Pediatric Nephrology, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA

Authors and Affiliations

  1. Division of Hematology–Oncology, Department of Pediatrics & Communicable Diseases, University of Michigan, Ann Arbor, MI, USA

    Mark Vander Lugt & Linda M. McAllister-Lucas

  2. Division of Pediatric Nephrology, Department of Pediatrics & Communicable Diseases, University of Michigan, F6865 Mott Hospital/SPC 5297, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109-5297, USA

    Ashton Chen & Neal B. Blatt

  3. Department of Pathology, University of Michigan, Ann Arbor, MI, USA

    Paul D. Killen

Authors
  1. Ashton Chen
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  2. Mark Vander Lugt
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  3. Linda M. McAllister-Lucas
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  4. Paul D. Killen
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  5. Neal B. Blatt
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Corresponding author

Correspondence to Neal B. Blatt.

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Chen, A., Vander Lugt, M., McAllister-Lucas, L.M. et al. An unusual case of membranous nephropathy associated with an ovarian tumor. Pediatr Nephrol 26, 2249–2251 (2011). https://doi.org/10.1007/s00467-011-1994-7

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  • DOI: https://doi.org/10.1007/s00467-011-1994-7

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