Cardiorespiratory fitness in young adults with a history of renal transplantation in childhood


Limited knowledge exists on cardiorespiratory fitness (CR fitness) in adults having a renal transplant (Rtx) during childhood. Our aim was to assess CR fitness (V02peak) with a maximal treadmill test in former Rtx children reaching adulthood (ped-tx, n = 31), compared to patients Rtx as adults (adult-tx, n = 17) and healthy controls (HC, n = 36). Median age was 26.9 (19–41), 28.6 (23.5–34) and 33.5 (20–42) years, respectively. Median time since first Rtx was 18.1 (7–29) and 3.7 (1.2–12.6) years. Body composition was measured by dual-energy X-ray absorptiometry (DXA). V02peak was median 37.9 (12.5–56.3), 40.8 (26.5–57.5), and 44.4 (29.5–65.6) ml kg –1min –1 in the ped-tx, adult-tx, and HC, respectively. Ped-tx had significantly lower V02peak compared to HC (p = 0.01). Adult-tx had higher exercise capacity (test duration) compared to ped-tx (median 10.5 (7.5–16) and 9 (6–14) min, respectively (p = 0.016). In multiple linear regression analysis, test duration, fat-free mass (FFM, kg) and Hgb (g/dl) were significant predictors of V02peak explaining 86% of its variance. There was no significant difference between ped-tx and adult-tx in V02peak. CR fitness depicts long-term health outcome in Rtx patients both in regard to physical functioning and is a plausible indirect marker of CV health.

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The authors gratefully acknowledge participants for their valuable contributions to this study, and to Kari Gjersum and Mai-Britt Lynum for coordinating services. This study was supported by grants from the Foundation of Renée and Bredo Grimsgaard, Oslo, Norway.

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Correspondence to Trine Tangeraas.

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Tangeraas, T., Midtvedt, K., Cvancarova, M. et al. Cardiorespiratory fitness in young adults with a history of renal transplantation in childhood. Pediatr Nephrol 26, 2041–2049 (2011).

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  • Pediatric
  • V02peak
  • Physical activity
  • Cardiovascular risk