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Cardiorespiratory fitness in young adults with a history of renal transplantation in childhood

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Abstract

Limited knowledge exists on cardiorespiratory fitness (CR fitness) in adults having a renal transplant (Rtx) during childhood. Our aim was to assess CR fitness (V02peak) with a maximal treadmill test in former Rtx children reaching adulthood (ped-tx, n = 31), compared to patients Rtx as adults (adult-tx, n = 17) and healthy controls (HC, n = 36). Median age was 26.9 (19–41), 28.6 (23.5–34) and 33.5 (20–42) years, respectively. Median time since first Rtx was 18.1 (7–29) and 3.7 (1.2–12.6) years. Body composition was measured by dual-energy X-ray absorptiometry (DXA). V02peak was median 37.9 (12.5–56.3), 40.8 (26.5–57.5), and 44.4 (29.5–65.6) ml kg –1min –1 in the ped-tx, adult-tx, and HC, respectively. Ped-tx had significantly lower V02peak compared to HC (p = 0.01). Adult-tx had higher exercise capacity (test duration) compared to ped-tx (median 10.5 (7.5–16) and 9 (6–14) min, respectively (p = 0.016). In multiple linear regression analysis, test duration, fat-free mass (FFM, kg) and Hgb (g/dl) were significant predictors of V02peak explaining 86% of its variance. There was no significant difference between ped-tx and adult-tx in V02peak. CR fitness depicts long-term health outcome in Rtx patients both in regard to physical functioning and is a plausible indirect marker of CV health.

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Acknowledgments

The authors gratefully acknowledge participants for their valuable contributions to this study, and to Kari Gjersum and Mai-Britt Lynum for coordinating services. This study was supported by grants from the Foundation of Renée and Bredo Grimsgaard, Oslo, Norway.

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Authors and Affiliations

  1. Department of Paediatric Medicine, Women and Children’s Division, Oslo University Hospital Rikshospitalet, Postboks 4950, Nydalen, 0424, Oslo, Norway

    Trine Tangeraas, Per Morten Fredriksen & Anna Bjerre

  2. Department of Organ Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway

    Karsten Midtvedt

  3. National Resource Center for Late Effects, Department of Oncology, Oslo University Hospital Rikshospitalet, Oslo, Norway

    Milada Cvancarova

  4. Department of Pediatrics, Haukeland University Hospital Bergen, Oslo, Norway

    Asle Hirth

  5. Division of Specialized Medicine and Surgery, Oslo University Hospital Rikshospitalet, Oslo, Norway

    Sigve Tonstad

  6. Department of Endocrinology, Oslo University Hospital Rikshospitalet, Oslo, Norway

    Gunhild Aker Isaksen

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  1. Trine Tangeraas
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Correspondence to Trine Tangeraas.

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Tangeraas, T., Midtvedt, K., Cvancarova, M. et al. Cardiorespiratory fitness in young adults with a history of renal transplantation in childhood. Pediatr Nephrol 26, 2041–2049 (2011). https://doi.org/10.1007/s00467-011-1898-6

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  • DOI: https://doi.org/10.1007/s00467-011-1898-6

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