Middle-term use of Cinacalcet in paediatric dialysis patients

Abstract

The effects of the calcimimetic drug Cinacalcet were assessed in six children with uncontrolled hyperparathyroidism secondary to stage 5 chronic kidney disease (CKD). Data were collected retrospectively regarding bone biochemistry and medications. Patients were between the ages of 11 months and 14 years on commencing Cinacalcet at initial doses of 0.4–1.4 mg/kg. Treatment, which was well tolerated in the majority and still on going in five patients, was for periods ranging between 3 months and 3 years. All six cases saw at least an 86% reduction in serum parathyroid hormone (PTH). Hypophosphataemia and/or hypocalcaemia were observed in three cases. Overall, achievement of UK Renal Association targets for corrected calcium (Ca), phosphate (P) and the calcium × phosphate product (Ca × P) were unaffected. We conclude that Cinacalcet is an effective treatment for correcting and sustaining correction of uncontrollable PTH levels seen in a difficult group of patients. Importantly, it has allowed the avoidance of parathyroidectomy for a significant time period in all cases. There remain questions about the effect of Cinacalcet on linear growth amongst paediatric dialysis patients, and future studies should aim to address this.

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Abbreviations

K/DOQI:

National Kidney Foundation Disease Outcomes Quality Initiative

Ca:

Corrected calcium

P:

Phosphate

PTH:

Parathyroid hormone

CaSR:

Calcium sensing receptor

HD:

Haemodialysis

PD:

Peritoneal dialysis

SHPT:

Secondary hyperparathyroidism

AlkP:

Alkaline phosphatase

FSGS:

Focal segmental glomerulosclerosis

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Correspondence to Caroline Platt.

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Platt, C., Inward, C., McGraw, M. et al. Middle-term use of Cinacalcet in paediatric dialysis patients. Pediatr Nephrol 25, 143–148 (2010). https://doi.org/10.1007/s00467-009-1294-7

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Keywords

  • Calcimimetic
  • End-stage renal failure
  • Metabolic bone disease
  • Paediatric
  • Calcium
  • Phosphate
  • Parathyroid hormone