Pulmonary thrombosis as the first manifestation of systemic lupus erythematosus in a 14-year-old boy

Pediatric Nephrology volume 24, pages857–861(2009)Cite this article

Abstract

We describe the case of a 14-year-old boy who presented with pulmonary embolism and who was subsequently found to have nephrotic syndrome due to lupus membranous nephropathy. He had no other signs of nephrotic syndrome or of systemic lupus erythematosus, such as edema or circulating lupus anticoagulants (antiphospholipid or anticardiolipin antibodies), and no hereditary coagulopathy. This case contributes to our understanding of unusual clinical presentations of systemic lupus erythematosus in children.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

US$ 39.95

Tax calculation will be finalised during checkout.

Fig. 1
Fig. 2
Fig. 3

References

  1. 1.

    Stein PD, Kayali F, Olson RE (2004) Incidence of venous thromboembolism in infants and children: data from the National Hospital Discharge Survey. J Pediatr 145:563–565

    Article  Google Scholar 

  2. 2.

    van Ommen CH, Heijboer H, Buller HR, Hirasing RA, Heijmans HS, Peters M (2001) Venous thromboembolism in childhood: a prospective two-year registry in The Netherlands. J Pediatr 139:676–681

    Article  Google Scholar 

  3. 3.

    Richardson MW, Allen GA, Monahan PE (2002) Thrombosis in children: current perspective and distinct challenges. Thromb Haemost 88:900–911

    CAS  Article  Google Scholar 

  4. 4.

    Citak A, Emre S, Sairin A, Bilge I, Nayir A (2000) Hemostatic problems and thromboembolic complications in nephrotic children. Pediatr Nephrol 14:138–142

    CAS  Article  Google Scholar 

  5. 5.

    Velasquez Forero F, Garcia Prugue N, Ruiz Morales N (1988) Idiopathic nephrotic syndrome of the adult with asymptomatic thrombosis of the renal vein. Am J Nephrol 8:457–462

    CAS  Article  Google Scholar 

  6. 6.

    Huang J, Yang J, Ding J (2000) Pulmonary embolism associated with nephrotic syndrome in children: a preliminary report of 8 cases. Chin Med J (Engl) 113:251–253

    CAS  Google Scholar 

  7. 7.

    Hoyer PF, Gonda S, Barthels M, Krohn HP, Brodehl J (1986) Thromboembolic complications in children with nephrotic syndrome. Risk and incidence. Acta Paediatr Scand 75:804–810

    CAS  Article  Google Scholar 

  8. 8.

    Singhal R, Brimble KS (2006) Thromboembolic complications in the nephrotic syndrome: pathophysiology and clinical management. Thromb Res 118:397–407

    CAS  Article  Google Scholar 

  9. 9.

    Zaffanello M, Franchini M (2007) Thromboembolism in childhood nephrotic syndrome: a rare but serious complication. Hematology 12:69–73

    Article  Google Scholar 

  10. 10.

    Llach F, Arieff AI, Massry SG (1975) Renal vein thrombosis and nephrotic syndrome. A prospective study of 36 adult patients. Ann Intern Med 83:8–14

    CAS  Article  Google Scholar 

  11. 11.

    Eddy AA, Symons JM (2003) Nephrotic syndrome in childhood. Lancet 362:629–639

    Article  Google Scholar 

  12. 12.

    Ponticelli C (2007) Membranous nephropathy. J Nephrol 20:268–287

    CAS  Google Scholar 

  13. 13.

    Cameron JS (1999) Lupus nephritis. J Am Soc Nephrol 10:413–424

    CAS  PubMed  Google Scholar 

  14. 14.

    Nathanson S, Salomon R, Ranchin B, Macher MA, Lavocat MP, Krier MJ, Baudouin V, Azema C, Bader-Meunier B, Deschenes G (2006) Prognosis of lupus membranous nephropathy in children. Pediatr Nephrol 21:1113–1116

    Article  Google Scholar 

  15. 15.

    Balow JE, Boumpas DT, Fessler BJ, Austin HA 3rd (1996) Management of lupus nephritis. Kidney Int Suppl 53:S88–S92

    CAS  PubMed  Google Scholar 

  16. 16.

    Bansal VK, Beto JA (1997) Treatment of lupus nephritis: a meta-analysis of clinical trials. Am J Kidney Dis 29:193–199

    CAS  Article  Google Scholar 

  17. 17.

    Flanc RS, Roberts MA, Strippoli GF, Chadban SJ, Kerr PG, Atkins RC (2004) Treatment for lupus nephritis. Cochrane Database Syst Rev 1:CD002922

    Google Scholar 

Download references

Author information

Affiliations

  1. Service de Pédiatrie, Centre Hospitalier Intercommunal de Créteil, 40 avenue de Verdun, 94000, Créteil, France

    Annie Harroche, Natascha Remus, Solenn Gaubicher, Christophe Delacourt & Fouad Madhi

  2. Service de néphrologie pédiatrique, Hôpital Trousseau, Paris, France

    Olivier Dunand

  3. Service d’anatomie pathologique, Centre Hospitalier Tenon, Paris, France

    Magali Colombat

Authors
  1. Annie Harroche
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Natascha Remus
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Solenn Gaubicher
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Olivier Dunand
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Magali Colombat
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Christophe Delacourt
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Fouad Madhi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Fouad Madhi.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Harroche, A., Remus, N., Gaubicher, S. et al. Pulmonary thrombosis as the first manifestation of systemic lupus erythematosus in a 14-year-old boy. Pediatr Nephrol 24, 857–861 (2009). https://doi.org/10.1007/s00467-008-1037-1

Download citation

Keywords

  • Pulmonary thrombosis
  • Nephrotic syndrome
  • Membranous nephropathy
  • Systemic lupus erythematosus