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Chronic kidney disease in children in Turkey

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Abstract

To determine the incidence, etiology and treatment patterns of chronic kidney disease (CKD) in children a questionnaire was sent to pediatric nephrology centers in Turkey, asking them to report patients under the age of 19 years who had estimated glomerular filtration rates (GFRs) of ≤75 ml/min per 1.73 m2 body surface area, diagnosed in 2005. Twenty-nine centers reported 282 patients (123 female/159 male; mean age 8.05 ± 5.25 years). Urological problems such as vesicoureteral reflux (18.5%), obstructive uropathy (10.7%) and neurogenic bladder (15.1%) were the leading causes of CKD. The majority of the patients were in stage V (32.5%), IV (29.8%) or III (25.8%). Growth retardation (49.6%) and secondary hyperparathyroidism (72.4%) were very frequent. The GFR levels correlated positively with hemoglobin/hematocrit and calcium levels and negatively with phosphorus and parathyroid hormone (PTH) levels (P < 0.05). Renal replacement therapies were initiated in 35.8% of the patients, peritoneal dialysis in 23%, hemodialysis in 10.6% and transplantation in 2.2%. This was the first multi-center, epidemiologic study done in children with CKD in Turkey. The most striking result was the predominance of vesicoureteral reflux (VUR) or related urological problems as the underlying causes of CKD. Thus, early diagnosis and treatment of these conditions are of vital importance to decrease the incidence of CKD in children.

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Acknowledgment

This study was presented as a poster and published in the abstracts book of the 14th Congress of the International Pediatric Nephrology Association held in Budapest between 31 August and 4 September 2007. The Chronic Kidney Disease working group (CKDWG) thank all participating centers. the names of which are given below, for their invaluable contribution to the data collection. This article was written by the CKDWG on behalf of all the physicians in the participating centers:

Adnan Menderes University: Ferah Sönmez

Akdeniz University: Sema Akman

Ankara University: Mesiha Ekim

Baskent University Adana Hospital: Nurcan Cengiz

Baskent University Ankara Hospital: Esra Baskın

Celal Bayar University: İpek Akil

Cukurova University: Aysun Karabay Bayazit

Dicle University: Aydın Ece

Dr. Behcet Uz Children’s Hospital: Mustafa Bak, Erkin Serdaroğlu

Dr. Sami Ulus Children’s Hospital: Ayşe Öner, Özlem Erdoğan

Ege University: Sevgi Mir

Erciyes University: Ruhan Düşünsel, M. Hakan Poyrazoğlu

Gülhane Military Medical Academy, Ankara: Faysal Gök

Gazi University: Oğuz Söylemezoğlu, Kibriya Fidan

Gaziantep University: Ayşe Balat, Mithat Büyükçelik

Göztepe Training and Research Hospital: Nurdan Yıldız

Hacettepe University: Rezan Topaloğlu

Istanbul University, Cerrahpasa: Salim Çalışkan, Nur Canpolat

Isparta Süleyman Demirel University: Faruk Öktem

Istanbul University: Ilmay Bilge

Karadeniz Technical University: Elif Bahat

Kocaeli University: Zelal Bircan

Marmara University: Harika Alpay, İbrahim Gökçe

Mersin University: Ali Delibaş

Ondokuz Mayıs University: Ozan Özkaya, Kenan Bek

Ministry of Health Ankara Diskapi Hospital: Nazlı Kara

Selçuk University, Meram: Harun Peru

Tepecik Training Hospital: Orhan Deniz Kara

Uludağ University: Osman Dönmez

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Authors and Affiliations

  1. Pediatric Nephrology, Ondokuz Mayis University, Kurupelit, Samsun, 55100, Turkey

    Kenan Bek

  2. Pediatric Nephrology, Faculty of Medicine, Akeniz University, Antalya, Turkey

    Sema Akman

  3. Pediatric Nephrology, Capa Medical Faculty, Istanbul University, Istanbul, Turkey

    Ilmay Bilge

  4. Pediatric Nephrology and Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey

    Rezan Topaloğlu

  5. Pediatric Nephrology, Cerrahpaba Medical Faculty, Istanbul University, Istanbul, Turkey

    Salim Çalışkan

  6. Pediatric Nephrology, Meram Medical Faculty, Selçuk University, Anatolia, Turkey

    Harun Peru

  7. Pediatric Nephrology, Faculty of Medicine, Başkent University, Adana, Turkey

    Nurcan Cengiz

  8. Pediatric Nephrology, Faculty of Medicine, Gazi University, Ankara, Turkey

    Oğuz Söylemezoğlu

Authors
  1. Kenan Bek
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  2. Sema Akman
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  3. Ilmay Bilge
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  4. Rezan Topaloğlu
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  5. Salim Çalışkan
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  6. Harun Peru
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  7. Nurcan Cengiz
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  8. Oğuz Söylemezoğlu
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Corresponding author

Correspondence to Kenan Bek.

Appendix: Data Form of the Turkish Society of Pediatric Nephrology (TSPN) chronic kidney disease working group

Appendix: Data Form of the Turkish Society of Pediatric Nephrology (TSPN) chronic kidney disease working group

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Bek, K., Akman, S., Bilge, I. et al. Chronic kidney disease in children in Turkey. Pediatr Nephrol 24, 797–806 (2009). https://doi.org/10.1007/s00467-008-0998-4

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  • DOI: https://doi.org/10.1007/s00467-008-0998-4

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