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Pediatric live-donor kidney transplantation in Mansoura Urology & Nephrology Center: a 28-year perspective

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Abstract

Our objective was to evaluate our overall experience in pediatric renal transplantation. Between March 1976 and March 2004, 1,600 live-donor kidney transplantations were carried out in our center; 216 of the patients were 18 years old or younger (mean age 12.9 years). There were 136 male patients and 80 female patients. The commonest causes of end-stage renal disease (ESRD) were renal dysplasia (22%), nephrotic syndrome (20%), hereditary nephritis (16%), and obstructive uropathy (16%). Of the donors, 94% were one-haplotype matched and the rest were identical. Pre-emptive transplantation was performed in 51 (23%) patients. Triple-therapy immunosuppression (prednisone + cyclosporine + azathioprine) was used in 78.2% of transplants. Rejection-free recipients constituted 47.7%. Hypertension (62%) was the commonest complication. A substantial proportion of patients (48%) were short, with height standard deviation score (SDS) less than −1.88. The overall infection rate was high, and the majority (53%) of infections were bacterial. The graft survival at 1 year, 5 years and 10 years were 93.4%, 73.3% and 48.2%, respectively, while the patients’ survival at 1, 5 and 10 years were 97.6%, 87.8% and 75.3%, respectively. Despite long-term success results of pediatric renal transplantation in a developing country, there is a risk of significant morbidity.

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Acknowledgment

The authors would like to thank Dr. Sherine Hamdy for her help in proofreading the article.

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Authors and Affiliations

  1. Mansoura Urology & Nephrology Center, Mansoura University, Mansoura, Egypt

    Amr A. El-Husseini, Mohamed A. Foda, Mohamed A. Bakr, Ahmed A. Shokeir, Mohamed A. Sobh & Mohamed A. Ghoneim

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  1. Amr A. El-Husseini
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  2. Mohamed A. Foda
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  3. Mohamed A. Bakr
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  4. Ahmed A. Shokeir
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  5. Mohamed A. Sobh
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  6. Mohamed A. Ghoneim
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Correspondence to Amr A. El-Husseini.

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El-Husseini, A.A., Foda, M.A., Bakr, M.A. et al. Pediatric live-donor kidney transplantation in Mansoura Urology & Nephrology Center: a 28-year perspective. Pediatr Nephrol 21, 1464–1470 (2006). https://doi.org/10.1007/s00467-006-0150-2

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  • DOI: https://doi.org/10.1007/s00467-006-0150-2

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