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Short-term outcomes and prognosis of laparoscopy-assisted total gastrectomy in elderly patients with stomach cancer

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Abstract

Background

The aim of this study was to evaluate the short-term outcomes and prognosis of laparoscopy-assisted total gastrectomy (LTG) in elderly patients with gastric cancer.

Methods

The clinical data of 275 patients aged over 65 years undergoing open total gastrectomy (OTG, n = 184) or laparoscopy-assisted total gastrectomy (LTG, n = 91) were reviewed from January 2015 to August 2017 at the First Affiliated Hospital of the University of Science and Technology of China. Short-term outcomes were compared between the two groups, and risk factors for postoperative complications were explored. In addition, the 2-year overall survival (OS) and disease-free survival (DFS) were investigated for both groups.

Results

Except for the ASA score (P = 0.01), there was no significant difference regarding patient baselines between the two groups. Patients in the LTG group had a longer operative time (P < 0.001), less intraoperative blood loss (P = 0.004), a shorter time of resumption to a semi-liquid diet (P < 0.001) and a shorter postoperative hospital stay (P = 0.001). The incidence of pulmonary complications was significantly lower in the LTG group than in the OTG group (4.4% vs. 13%, P = 0.026). The number of lymph nodes harvested in the LTG group was higher than that in the OTG group (20.7 ± 7.4 vs. 17.5 ± 6.9, P = 0.001), and the proportion of patients with TNM stage III gastric cancer was higher in the LTG group than in the OTG group (P = 0.035). There was no significant difference in the 2-year OS rate or 2-year DFS rate between the two groups (P = 0.057 and P = 0.344). Sex, age, preoperative comorbidity, intraoperative blood loss, and TNM stage were identified as independent prognostic factors for postoperative survival.

Conclusion

Comparing with OTG, LTG is feasible and contributes to less surgical trauma and a faster recovery after total gastrectomy. In addition, LTG contributes to a lower risk of postoperative pulmonary complications. Regarding oncological results, LTG is more effective for lymph node dissection and has a comparable long-term prognosis as OTG.

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Funding

This project was funded by the National Natural Science Foundation of China (81501601) and the Natural Science Foundation of An Hui Province of China (1608085QH198).

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Authors and Affiliations

  1. Department of General Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, China

    Dongliang Liu, Lichuan Liang & Zhiqiang Zhu

  2. Department of General Surgery, The First Hospital Affiliated to the University of Science and Technology of China, Lujiang Road 17, Lu Yang District, Hefei, Anhui, China

    Liu Liu, Zhiqiang Zhu, Shaojun Liu, Lei Hu, Yiren He, Yu Fang & Xiao Wan

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  1. Dongliang Liu
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  2. Lichuan Liang
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  3. Liu Liu
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Contributions

DLL, LL and ZQZ were involved in the study conception and design. DLL, LL and XW performed the data acquisition. DLL, LCL and SJL performed the analysis and interpretation of the data. DLL, LH, and YRH drafted the manuscript. DLL, YF and ZQZ critically revised the manuscript.

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Correspondence to Liu Liu or Zhiqiang Zhu.

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Disclosure

Dongliang LIU, Lichuan LIANG, Liu LIU, Zhiqiang ZHU, Shaojun LIU, Lei HU, Yiren HE, Yu FANY, Xiao WAN have no conflicts of interest or financial ties to disclose.

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Liu, D., Liang, L., Liu, L. et al. Short-term outcomes and prognosis of laparoscopy-assisted total gastrectomy in elderly patients with stomach cancer. Surg Endosc 34, 5428–5438 (2020). https://doi.org/10.1007/s00464-019-07338-0

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