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Laparoscopic versus open subtotal gastrectomy for adenocarcinoma of the stomach in a Western population: peri-operative and 5-year oncological outcomes

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Abstract

Background

This study compares the peri-operative and long-term oncological outcomes for laparoscopic subtotal gastrectomy (LSG) versus open subtotal gastrectomy (OSG) for adenocarcinoma of the stomach in a Western population.

Methods

A retrospective, intention-to-treat analysis study was conducted for consecutive patients undergoing gastrectomy with curative intent for adenocarcinoma of the stomach between November 2006 and October 2016. Univariate analysis was used to compare peri-operative outcomes between LSG and OSG. Logistic regression with bootstrapping validation was used to identify independent risk factors for predicting 2-year overall survival.

Results

The final analysis included 79 patients. When comparing LSG (n = 30) to OSG (n = 49), there was no difference in the number of resected lymph nodes (36 (IQR 24.3–44) vs. 42 (IQR 28–59), p = 0.165), a reduction in intra-operative blood loss (150 ml (IQR 100–250) vs. 553 ml (IQR 338–1075), p < 0.001) and an increase incidence of post-operative bleeding (3 patients vs. 0, p = 0.024), respectively. Five-year overall survival for LSG (n = 22) versus OSG (n = 20) was 63.6% and 50% (p = 0.372), respectively. The number of positive lymph nodes [OR 0.64 (CI 0.47–0.88), p = 0.006] was the only significant independent risk factor for 2-year overall survival. Pre-operative ASA grading and operative approach did not influence survival outcomes at 2 years.

Conclusion

This study suggests that LSG is comparable to OSG in Western patients with respect to oncological quality and peri-operative morbidity. Two-year overall survival is predicted by the number of positive lymph nodes and not the operative access employed for resection.

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Acknowledgements

The authors received no financial support for this work. The authors would like to show their gratitude to Sukhpal Singh, Krishna K Singh and Yuen Soon who perfomed surgeries in this cohort of patients. We would also like to thank Izhar Bagwan and Poonam Pingle for the histopathological assessment of the cancer resection specimens.

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Authors and Affiliations

  1. Oesophago-gastric Unit, Royal Surrey County Hospital, Egerton Road, Guildford, GU2 7XX, UK

    Nima Abbassi-Ghadi, Sanja Durakovic, Piers Gatenby, Javed Sultan & Shaun R. Preston

  2. Department of Gastrointestinal Oncology, Centre Oscar Lambret, Lille, France

    Guillaume Piessen

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  1. Nima Abbassi-Ghadi
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  2. Sanja Durakovic
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  3. Guillaume Piessen
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  4. Piers Gatenby
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Correspondence to Shaun R. Preston.

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Drs. N Abbassi-Ghadi, S Durakovic, G Piessen, P Gatenby, J Sultan, SR Preston have no conflicts of interest or financial ties to disclose.

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Abbassi-Ghadi, N., Durakovic, S., Piessen, G. et al. Laparoscopic versus open subtotal gastrectomy for adenocarcinoma of the stomach in a Western population: peri-operative and 5-year oncological outcomes. Surg Endosc 34, 3818–3826 (2020). https://doi.org/10.1007/s00464-019-07146-6

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