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Minimally invasive esophagectomy attenuates the postoperative inflammatory response and improves survival compared with open esophagectomy in patients with esophageal cancer: a propensity score matched analysis

  • Kotaro Yamashita
  • Masayuki Watanabe
  • Shinji Mine
  • Tasuku Toihata
  • Ian Fukudome
  • Akihiko Okamura
  • Masami Yuda
  • Masaru Hayami
  • Naoki Ishizuka
  • Yu Imamura
Article

Abstract

Background

Minimally invasive esophagectomy (MIE) for patients with esophageal cancer has recently spread worldwide. However, whether MIE is less invasive has not yet been fully evaluated.

Methods

We retrospectively analyzed data from 551 patients who underwent curative esophagectomy for esophageal cancer from 2005 to 2014: 145 patients underwent minimally invasive esophagectomy (MIE) and 406 patients underwent open transthoracic esophagectomy (OE). We compared postoperative CRP levels with propensity score matching. In addition, long-term outcomes were also compared between the groups.

Results

Operative time was significantly longer, and intraoperative blood loss was significantly less in the MIE group compared with the OE group. Although the incidence of postoperative complications was similar between the 2 groups, postoperative serum CRP levels during the first 3 and 5 postoperative days and peak postoperative CRP levels were significantly lower after MIE versus OE (MIE vs. OE, median, 15.21 vs. 19.50 mg/dl; P < 0.001). The MIE group had significantly more favorable disease-free survival (DFS) and overall survival (OS) rates than the OE group (3-year DFS rate, 81.7 vs. 69.3%, log-rank P = 0.021; 3-year OS rate, 89.9 vs. 79.2%, log-rank P = 0.007). MIE was an independent prognostic factor for patients with esophageal cancer. The incidence of regional lymph node recurrence was lower in the MIE group.

Conclusions

MIE significantly attenuated postoperative serum CRP levels compared with OE. MIE could contribute to improved survival.

Keywords

Minimally invasive esophagectomy Inflammatory response Serum C-reactive protein Disease-free survival 

Notes

Compliance with ethical standards

Disclosures

Drs. Kotaro Yamashita, Masayuki Watanabe, Shinji Mine, Tasuku Toihata, Ian Fukudome, Akihiko Okamura, Masami Yuda, Masaru Hayami, Naoki Ishizuka, and Yu Imamura have no conflicts of interest or financial ties to disclose.

Supplementary material

464_2018_6187_MOESM1_ESM.tif (654 kb)
Supplementary material 1 (TIF 653 KB)
464_2018_6187_MOESM2_ESM.docx (31 kb)
Supplementary material 2 (DOCX 31 KB)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Kotaro Yamashita
    • 1
  • Masayuki Watanabe
    • 1
  • Shinji Mine
    • 1
  • Tasuku Toihata
    • 1
  • Ian Fukudome
    • 1
  • Akihiko Okamura
    • 1
  • Masami Yuda
    • 1
  • Masaru Hayami
    • 1
  • Naoki Ishizuka
    • 2
  • Yu Imamura
    • 1
  1. 1.Department of Gastroenterological SurgeryCancer Institute Hospital of the Japanese Foundation for Cancer ResearchTokyoJapan
  2. 2.Clinical Trial Planning and ManagementCancer Institute Hospital of the Japanese Foundation for Cancer ResearchTokyoJapan

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