Surgical Endoscopy

, Volume 32, Issue 5, pp 2409–2419 | Cite as

Hypopharyngeal multichannel intraluminal impedance leads to the promising outcome of antireflux surgery in Japanese population with laryngopharyngeal reflux symptoms

  • Takeshi Suzuki
  • Yosuke Seki
  • Yoshitaka Okamoto
  • Toshitaka Hoppo



Clinical characteristics of laryngopharyngeal reflux (LPR) in Japanese population remain unclear, and its treatment outcome is suboptimal. The objectives of this study were to evaluate Japanese patients with LPR symptoms using hypopharyngeal multichannel intraluminal impedance (HMII) and to assess the outcome of antireflux surgery (ARS).


Subjects included patients who had LPR symptoms for > 12 weeks or laryngoscopic findings suggestive of LPR and underwent laryngoscopy and esophageal testing including HMII. Abnormal proximal exposure (APE) was defined as LPR ≥ 1/day and/or full column reflux (FCR) (reflux 2 cm distal to the upper esophageal sphincter) ≥ 5/day on HMII. Patients with APE were offered ARS and the outcome of ARS was objectively assessed using Reflux Symptom Index (RSI).


From July 2015 to September 2016, 52 patients with LPR symptoms (28 men, 24 women, median BMI 22.3) underwent HMII, and 38 patients (73%) had APE. Of them, 29 (76%) patients were not obese (BMI < 25) and 19 (50%) patients had a negative DeMeester score. Approximately one-third of LPR and FCR events were non-acid in the distal esophagus. A positive symptom-association probability was seen only in 18 patients (35%). Mild esophagitis and hiatal hernia were found in 5 (10%) and 23 (48%) patients, respectively. All 12 patients (100%) who had undergone ARS were able to discontinue PPI and had a significant improvement in the RSI scores postoperatively (22.9 ± 10.0 vs. 6.8 ± 6.8, p < .001).


APE was frequently observed in Japanese patients with LPR symptoms. Obesity and esophagitis were uncommon in this population. Since a large number of patients with APE had negative DeMeester score and proximal reflux events were often non-acid, a conventional pH monitoring is insufficient. HMII is crucial to evaluate patients with LPR symptoms as the documentation of APE is a key for successful outcome of ARS.


Laryngopharyngeal reflux Abnormal proximal exposure Hypopharyngeal multichannel intraluminal impedance Antireflux surgery Japanese 



Laryngopharyngeal reflux


Gastroesophageal reflux disease


Proton pump inhibitor


Multichannel intraluminal impedance


Hypopharyngeal MII


Abnormal proximal exposure


Full column reflux


Upper esophageal sphincter


Antireflux surgery


Body mass index


Reflux symptom index


Frequency scale for the symptoms of GERD


Reflux finding score


Los Angeles


High-resolution manometry


Esophagogastric junction


Ineffective esophageal motility


Lower esophageal sphincter


Symptom-association probability


Non-erosive gastroesophageal reflux disease



We thank Tadanao Takeno, Urara Funakoshi for her technical assistance.

Compliance with ethical standards


Drs. Takeshi Suzuki, Yosuke Seki, Yoshitaka Okamoto, and Toshitaka Hoppo have no conflicts of interest or financial tie to disclose.


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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Takeshi Suzuki
    • 1
  • Yosuke Seki
    • 2
  • Yoshitaka Okamoto
    • 1
  • Toshitaka Hoppo
    • 3
  1. 1.Department of Otolaryngology, Head and Neck Surgery, Graduate School of MedicineChiba UniversityChibaJapan
  2. 2.Minimally Invasive Surgery Center, Yotsuya Medical CubeTokyoJapan
  3. 3.Esophageal & Lung InstituteAllegheny Health NetworkPittsburghUSA

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