Surgical Endoscopy

, Volume 32, Issue 3, pp 1133–1140 | Cite as

Oncologic outcomes following laparoscopic colon cancer resection for T4 lesions: a case–control analysis of 7-years’ experience

  • Piera Leon
  • Michele Giuseppe Iovino
  • Fabiola Giudici
  • Antonio Sciuto
  • Nicolò de Manzini
  • Diego Cuccurullo
  • Francesco Corcione



According to many Societies’ guidelines, patients presenting with clinical T4 colorectal cancer should conventionally be approached by a laparotomy. Results of emerging series are questioning this attitude.


We retrospectively analysed the oncologic outcomes of 147 patients operated on between June 2008 and September 2015 for histologically proven pT4 colon cancers. All patients were treated with curative intent, either by a laparoscopic or open “en bloc” resection.


Median operative time, blood loss and hospital length of stay were significantly reduced in the laparoscopic group. Postoperative surgical complication rate and 30-day mortality did not significantly differ between the two groups ( p = 0.09 and p = 0.99, respectively). R1 resection rate and lymph nodes harvest, as well, did not remarkably differ when comparing the two groups. In the laparoscopic group, conversion rate was 19%. Long-term outcomes were not affected in patients who had undergone conversion. Five-year overall survival and disease-free survival did not significantly differ between the two groups (44.6% and 40.3% vs. 39.4% and 38.9%). Locally advanced stages (IIIB–IIIC) and R1 resections were detected as independent prognostic factors for overall survival.


Laparoscopic approach might be safe and acceptable for locally advanced colon cancer and does not jeopardize the oncologic results. Conversion to open surgery should be a part of a strategy as it does not seem to adversely affect perioperative and long-term outcomes. We consider laparoscopy, in expert hands, the last diagnostic tool and the first therapeutic approach for well-selected locally advanced colon cancers. Larger prospective studies are needed to widely assess this issue.


T4 colon cancer Locally advanced colon cancers Infiltrating colon cancers Laparoscopy Oncological results Multi-visceral resection 


Compliance with ethical standards


Drs. Piera Leon, Michele Giuseppe Iovino, Fabiola Giudici, Antonio Sciuto, Nicolò de Manzini, Diego Cuccurullo and Francesco Corcione have no conflicts of interest or financial ties to disclose.


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© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.Department of Medical, Surgical and Health Sciences, General Surgery ClinicUniversity of TriesteTriesteItaly
  2. 2.Department of General Surgery, Azienda Ospedaliera Dei ColliMonaldi HospitalNaplesItaly

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