Lateralisation in Parkinson disease

  • P. Riederer
  • K. A. Jellinger
  • P. Kolber
  • G. Hipp
  • J. Sian-Hülsmann
  • R. Krüger
Review

Abstract

Asymmetry of dopaminergic neurodegeneration and subsequent lateralisation of motor symptoms are distinctive features of Parkinson’s disease compared to other forms of neurodegenerative or symptomatic parkinsonism. Even 200 years after the first description of the disease, the underlying causes for this striking clinicopathological feature are not yet fully understood. There is increasing evidence that lateralisation of disease is due to a complex interplay of hereditary and environmental factors that are reflected not only in the concept of dominant hemispheres and handedness but also in specific susceptibilities of neuronal subpopulations within the substantia nigra. As a consequence, not only the obvious lateralisation of motor symptoms occurs but also patterns of associated non-motor signs are defined, which include cognitive functions, sleep behaviour or olfaction. Better understanding of the mechanisms contributing to lateralisation of neurodegeneration and the resulting patterns of clinical phenotypes based on bilateral post-mortem brain analyses and clinical studies focusing on right/left hemispheric symptom origin will help to develop more targeted therapeutic approaches, taking into account subtypes of PD as a heterogeneous disorder.

Keywords

Parkinson’s disease Parkinsonism Asymmetry Lateralisation Dopamine Handedness Genetics 

Abbreviations

ß-amyloid

aPS

atypical Parkinsonian Syndrome

α-Syn

α-synuclein

ß-CIT

iodine-123-(2-carboxymethoxy-3-(4-iodophenyl)tropane)

DASS

depression anxiety stress scales

DSB

definite suicidal behaviour

DA

dopamine

DAT

dopamine transporter

18F-DOPA

fluorine-18-labelled fluorodopa

DTI

Diffusion Tensor Imaging

FDG

fluordesoxyglucose

GBA

glucocerebrosidase

HELP

Help Advance Luxembourg’s Parkinson Research Study

LB

Lewy body

LC

locus coeruleus

LPD

left-dominant Parkinson’s disease

LBD

Lewy body dementia

LOPD

late-onset Parkinson’s disease

LRRK2

leucine-rich repeat kinase 2

MDS

International Parkinson and Movement Disorder Society

MRI

magnetic resonance imaging

MSA

multiple system atrophy

MSA-P

multiple system atrophy-type parkinson

MOCA

Montreal Cognitive Assessment

MPTP

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

NAA

N-acetylaspartate

OB

olfactory bulb

6-OHDA

6-hydroxydopamine

PD

Parkinson’s disease

PDD

Parkinson’s disease with dementia

PSP

progressive supranuclear palsy

PET

positron emission tomography

PFF

preformed fibrils

REM

rapid eye movement

RPD

right-dominant Parkinson’s disease

RN

raphe nucleus

SN

substantia nigra

SNc

substantia nigra pars compacta

SPECT

single-photon-emission computed tomography

TH

tyrosine hydroxylase

UPDRS

United Parkinson’s Disease Rating Scale

YOPD

young-onset Parkinson’s disease

Notes

Acknowledgements

The work of RK, GH and PK was supported by grants from the Luxembourg National Research Fund (FNR) within the National Centre of Excellence in Research on Parkinson’s disease (NCER-PD), the PEARL programme (FNR; FNR/P13/6682797 to RK) and by the European Union’s Horizon2020 research and innovation program under grant agreement No. 692320 (CENTRE-PD to RK).

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • P. Riederer
    • 1
    • 2
  • K. A. Jellinger
    • 3
  • P. Kolber
    • 4
  • G. Hipp
    • 4
  • J. Sian-Hülsmann
    • 5
  • R. Krüger
    • 4
  1. 1.Center of Mental Health, Clinic and Policlinic for Psychiatry, Psychosomatics and PsychotherapyUniversity Hospital WürzburgWürzburgGermany
  2. 2.Psychiatry Department of Clinical ResearchUniversity of Southern Denmark, Odense University HospitalOdense CDenmark
  3. 3.Institute of Clinical NeurobiologyViennaAustria
  4. 4.Parkinson Research ClinicCentre Hospitalier de LuxembourgLuxembourgLuxembourg
  5. 5.Department of Medical PhysiologyUniversity of NairobiNairobiKenya

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