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Common variants for atrial fibrillation: results from genome-wide association studies

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Abstract

Atrial fibrillation (AF) affects more than 5 million people worldwide; however, none of the anti-arrhythmic drugs available now are entirely optimal in terms of efficacy and safety. A better understanding of the molecular mechanism of AF will facilitate the process of finding new strategies to prevent AF. As the non-familial AF is the major form of AF, identifying common variants for AF in these populations by genome-wide association studies will definitely accelerate this process. This review summarizes the recently identified common AF variants on 4q25, 16q22, and 1q21 and discusses their implications for the clinic.

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Acknowledgments

This work was supported by the Shanghai Municipal Natural Science Foundation (10ZR1433100, to Xingyuan Liu).

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Authors and Affiliations

  1. Department of Pediatrics, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China

    Xinyuan Liu

  2. Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, Shanghai, 200092, China

    Xinyuan Liu, Jiangmin Zhao & Junjie Xiao

  3. Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China

    Fei Wang

  4. Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA

    Ashley C. Knight & Junjie Xiao

  5. Department of Radiology, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China

    Jiangmin Zhao

Authors
  1. Xinyuan Liu
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  2. Fei Wang
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  3. Ashley C. Knight
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  4. Jiangmin Zhao
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  5. Junjie Xiao
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Corresponding authors

Correspondence to Jiangmin Zhao or Junjie Xiao.

Additional information

X. Liu, F. Wang, J. Xiao and J. Zhao contributed equally to this work.

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Liu, X., Wang, F., Knight, A.C. et al. Common variants for atrial fibrillation: results from genome-wide association studies. Hum Genet 131, 33–39 (2012). https://doi.org/10.1007/s00439-011-1052-3

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  • DOI: https://doi.org/10.1007/s00439-011-1052-3

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