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Parasitology Research

, Volume 97, Supplement 1, pp S58–S64 | Cite as

Field evaluation of the efficacy and safety of emodepside/praziquantel spot–on solution against naturally acquired nematode and cestode infections in domestic cats

  • G. Altreuther
  • J. Buch
  • S. D. Charles
  • W. L. Davis
  • K. J. Krieger
  • I. Radeloff
Original Paper

Abstract

Two controlled, blinded and randomized multi–site clinical field studies evaluated the efficacy and safety of emodepside/praziquantel spot–on in the treatment of gastrointestinal nematode and cestode infections in cats. In a study conducted in Europe, faecal egg count reductions of >98% for all nematode eggs and eggs of Toxocara cati, respectively, were observed in cats treated with emodepside/praziquantel spot–on (Profender®, Bayer AG, Leverkusen, Germany). For a positivecontrol product containing selamectin (Stronghold) reductions of >95% were observed. A 100% reduction of faecal eggs and proglottids was observed in cats treated with emodepside/praziquantel spot–on that were infected with cestodes. In a study conducted in North America, cats were treated with either emodepside/praziquantel spot–on plus a placebo tablet or a combination of two control products containing, respectively, selamectin (Revolution) and epsiprantel (Cestex). Faecal egg count reduction for eggs of T. cati was >99% for both treatments. For faecal eggs and proglottids of Dipylidium caninum reductions of >99 and >97% were recorded for cats treated with emodepside/praziquantel spot–on and the control group, respectively. No adverse reactions were observed in the European study, and only mild ones of short duration in a few cats from both treatment groups of the North American study. The two studies demonstrated that emodepside/praziquantel spot–on is highly efficacious and safe under field conditions.

Keywords

Praziquantel Control Product Placebo Tablet Gastrointestinal Nematode North American Study 

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • G. Altreuther
    • 1
  • J. Buch
    • 2
  • S. D. Charles
    • 2
  • W. L. Davis
    • 2
  • K. J. Krieger
    • 1
  • I. Radeloff
    • 3
  1. 1.Bayer HealthCare AGAnimal Health Division, R&D ParasiticidesLeverkusenGermany
  2. 2.Bayer HealthCare LCCAnimal Health DivisionKansasUSA
  3. 3.Klifovet AGMunichGermany

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