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Parasitology Research

, Volume 97, Supplement 1, pp S41–S50 | Cite as

Evaluation of the efficacy of emodepside plus praziquantel topical solution against ascarid infections (Toxocara cati or Toxascaris leonina) in cats

  • C. R. Reinemeyer
  • S. D. Charles
  • J. Buch
  • T. Settje
  • G. Altreuther
  • L. Cruthers
  • J. W. McCall
  • D. R. Young
  • C. Epe
Original Paper

Abstract

Eleven controlled studies were conducted in the United States and Europe to evaluate the efficacy of a topical solution of emodepside (3 mg/kg)+praziquantel (12 mg/kg) (Profender®, Bayer AG, Leverkusen, Germany) against infection with various stages of the ascarid nematodes Toxocara cati and Toxascaris leonina. Infections were induced by administration of larvated ascarid eggs, and stage–specific efficacy was evaluated by treating cats at scheduled intervals post–inoculation. All studies featured random allocation to treatment groups, placebo–treated control animals and assessment of outcome measures by masked personnel. The product (emodepside+praziquantel topical solution) was 100% effective against mature adults and immature adult T. cati. In addition, it was 96.8% effective against third stage larvae and at least 99.4% effective against fourth stage larvae of T. cati, respectively. Efficacy against mature, immature adult and L4 stages of T. leonina exceeded 93.4%, but regulatory “adequacy of infection” criteria were not met in sorne studies. No adverse reactions to treatment were noted in cats treated with the emodepside+praziquantel topical solution.

Keywords

Praziquantel Emodepside Fecal Examination Topical Solution Worm Count 

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • C. R. Reinemeyer
    • 1
  • S. D. Charles
    • 2
  • J. Buch
    • 2
  • T. Settje
    • 2
  • G. Altreuther
    • 3
  • L. Cruthers
    • 4
  • J. W. McCall
    • 5
  • D. R. Young
    • 6
  • C. Epe
    • 7
  1. 1.East Tennessee Clinical ResearchKnoxvilleUSA
  2. 2.Bayer HealthCare LLCAnimal Health DivisionKansasUSA
  3. 3.Bayer HealthCare AGAnimal Health Division, R&D ParasiticidesLeverkusenGermany
  4. 4.Professional Laboratory Research ServicesUSA
  5. 5.TRS LaboratoriesUSA
  6. 6.Young Veterinary Research ServicesTurlockUSA
  7. 7.Institute of ParasitologyHannover School of Veterinary MedicineHannoverGermany

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