Investigation of a novel brachytherapy ureteral stent: trial studies on normal beagle dogs

Abstract

Purpose

To evaluate the safety and feasibility of a newly designed 125I brachytherapy ureteral stent (BUS) in normal dogs.

Methods

A BUS loaded with 10 125I seeds (Group A: 0.8 mCi, Group B: 0.4 mCi, Group C: 0 mCi) was designed and tested in 27 normal beagle dogs. Routine blood tests, gross observations, cumulative radiation doses, tissue reaction assessed by hematoxylin–eosin/Masson staining, mRNA analysis by RT-qPCR and protein expression of Caspase-3, Collagen I, PCNA, and α-SMA were performed at 2, 4 and 8 weeks.

Results

The BUS was implanted successfully in all dogs (27/27) without surgery-related death. The ureter diameter and radiation injury score increased along with radiation accumulation (p < 0.05). Histopathologic analysis showed necrotic tissue and lateral fibrosis to different extents in the ureteral walls that gradually increased in all groups (p < 0.05); however, epithelial cell proliferation in groups A and B was lighter than that in the control group (p < 0.05).

Conclusion

Placement of the newly designed 125I BUS was safe and feasible in dogs, and clinical studies are required to test its use in humans.

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Funding

This work was supported by the Key Scientific Research Projects of Higher Education Institutions in Henan Province [Grant number: 20A320024].

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Correspondence to Xinwei Han or Jianzhuang Ren.

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The authors declare that they have no conflict of interest.

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This study was approved by the Ethics Committee of the Affiliated Hospital of Zhengzhou University, Henan, People’s Republic of China.

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Jiao, D., Yao, Y., Xu, K. et al. Investigation of a novel brachytherapy ureteral stent: trial studies on normal beagle dogs. J Cancer Res Clin Oncol (2021). https://doi.org/10.1007/s00432-021-03513-w

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Keywords

  • Ureteral stent
  • Brachytherapy
  • Animal study
  • 125Iodine
  • Urinary system