Fig. 5 | Journal of Cancer Research and Clinical Oncology

Fig. 5

From: Resveratrol induces PD-L1 expression through snail-driven activation of Wnt pathway in lung cancer cells

Fig. 5

Resveratrol suppresses the proliferation and cytokine secretion by T cells. a, b Flow cytometric assessment of apoptosis showed that apoptosis levels of Jurkat T cells co-cultured either with PD-L1 overexpressed H1299 cells (a) or resveratrol treated H1299 cells (b) are increased. c Jurkat T cells were grown onto six-well plates and then treated with PMA (100 ng/ml) for 12 h. IFN-γ levels is strongly increased in Jurkat T cells stimulated with PMA. d PMA-stimulated Jurkat T cells were co-cultured either with resveratrol-treated or PD-L1 overexpressed H1299 cells. Compared with cells co-cultured with resveratrol-untreated and PD-L1 cDNA untransfected H1299 cells, resveratrol-treated and PD-L1 overexpressed H1299 cells inhibit IFN-γ production of co-cultured Jurkat T cells. e The correlations between Snail and PD-L1 expression from GEO database and the correlations between Snail and Axin2 expression from TCGA data set (TCGA-LUSC). The Spearman’s rank correlation coefficient (\(\rho\)) and the p values were calculated

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