Long-term efficacy of ultrasound-guided low power microwave ablation for the treatment of primary papillary thyroid microcarcinoma: a 3-year follow-up study
- 18 Downloads
To evaluate the safety and efficacy of ultrasound-guided low-power microwave ablation (MWA) for the treatment of papillary thyroid microcarcinoma (PTMC) with a 3-year follow-up.
A total of 21 nodules diagnosed as PTMC from the 15 patients were performed with MWA at a power of 20 W. The images of the nodules were recorded by ultrasound before MWA and 1, 3, 6, 12 months after MWA, and every 6 months thereafter, respectively. The volumes of the nodules were compared before MWA and at each follow-up point after MWA. The volume reduction rate (VRR) of nodules was also calculated.
The mean volume of the nodules was 134.3 ± 129.8 mm3 initially (the range was 7.4–423.8 mm3), which decreased significantly to 2.3 ± 10.5 mm3 (the range was 0–48.1 mm3) of the ablation area (P = 0.000) at the follow-up point of 36 months with a mean VRR as 98.78 ± 5.61% (the range was 74.28–100%). During the follow-up period (the range was 36–48 months), 20 of the 21 nodules were completely absorbed and no recurrent nodule was found.
After a long-term follow-up of 3 years, the low power MWA showed a good safety and efficacy for the treatment of PTMC. In addition to surgery and active surveillance, MWA might be another alternative for patients with PTMC.
KeywordsThermal ablation Microwave Ultrasound Thyroid Papillary carcinoma
This study was funded by the Finance Department of Jilin Province (no. SCZSY201701) and the Jilin Provincial Health and Family Planning Commission (no. 2016ZC032).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Human and animal rights statement
The studies have been approved by the appropriate institutional research ethics committee and have been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. This manuscript does not contain any studies with animals by any of the authors.
Informed consent was obtained from all individual participants included in the study.
- Gharib H et al (2016) American Association of Clinical Endocrinologists, American College of Endocrinology, and Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules—2016 update. Endocr Pract 22:622–639. https://doi.org/10.4158/EP161208.GL CrossRefPubMedGoogle Scholar
- Haugen BR et al (2016) 2015 American Thyroid Association Management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association guidelines task force on thyroid nodules and differentiated Thyroid Cancer. Thyroid 26:1–133. https://doi.org/10.1089/thy.2015.0020 CrossRefPubMedPubMedCentralGoogle Scholar
- Qu P, Yu X, Liang P, Cheng Z, Han Z, Liu F, Yu J (2013) Contrast-enhanced ultrasound in the characterization of hepatocellular carcinomas treated by ablation: comparison with contrast-enhanced magnetic resonance imaging. Ultrasound Med Biol 39:1571–1579. https://doi.org/10.1016/j.ultrasmedbio.2013.03.030 CrossRefGoogle Scholar