Brain Structure and Function

, Volume 223, Issue 4, pp 1747–1778 | Cite as

Efferents of anterior cingulate areas 24a and 24b and midcingulate areas 24aʹ and 24bʹ in the mouse

  • Clémentine Fillinger
  • Ipek Yalcin
  • Michel Barrot
  • Pierre Veinante
Original Article


The anterior cingulate cortex (ACC), constituted by areas 25, 32, 24a and 24b in rodents, plays a major role in cognition, emotion and pain. In a previous study, we described the afferents of areas 24a and 24b and those of areas 24aʹ and 24bʹ of midcingulate cortex (MCC) in mice and highlighted some density differences among cingulate inputs (Fillinger et al., Brain Struct Funct 222:1509–1532, 2017). To complete this connectome, we analyzed here the efferents of ACC and MCC by injecting anterograde tracers in areas 24a/24b of ACC and 24aʹ/24bʹ of MCC. Our results reveal a common projections pattern from both ACC and MCC, targeting the cortical mantle (intracingulate, retrosplenial and parietal associative cortex), the non-cortical basal forebrain, (dorsal striatum, septum, claustrum, basolateral amygdala), the hypothalamus (anterior, lateral, posterior), the thalamus (anterior, laterodorsal, ventral, mediodorsal, midline and intralaminar nuclei), the brainstem (periaqueductal gray, superior colliculus, pontomesencephalic reticular formation, pontine nuclei, tegmental nuclei) and the spinal cord. In addition to an overall denser ACC projection pattern compared to MCC, our analysis revealed clear differences in the density and topography of efferents between ACC and MCC, as well as between dorsal (24b/24bʹ) and ventral (24a/24aʹ) areas, suggesting a common functionality of these two cingulate regions supplemented by specific roles of each area. These results provide a detailed analysis of the efferents of the mouse areas 24a/24b and 24aʹ/24bʹ and achieve the description of the cingulate connectome, which bring the anatomical basis necessary to address the roles of ACC and MCC in mice.


Rodent’s cingulate cortex Prefrontal cortex Tract-tracing Connectome 



3rd ventricle


4th ventricle


Facial nerve


Anterior commissure, anterior part


Accumbens N, core region


Accumbens N, shell region


Anterior cingulate cortex


Anterodorsal thalamic N


Anterior hypothalamic area, central part


Anterior hypothalamic area, posterior part


Agranular insular cortex


Anteromedial thalamic N


Anterior olfactory N, medial part


Anterior olfactory N, posterior part


Anterior pretectal N




Primary auditory cortex


Anteroventral thalamic N


Barrington’s N


Basolateral amygdaloid N, anterior part


Field CA1 of the hippocampus


Corpus callosum




Central gray




Centrolateral thalamic N


Central medial thalamic N


Cerebral peduncle


Caudate putamen


Dorsal hippocampal commissure


Dorsal lateral geniculate N


Deep gray layer of the superior colliculus


Deep white layer of the superior colliculus


Dorsal raphe nucleus


Dorsal subiculum


Dorsal tenia tecta


External capsule


Ectorhinal cortex


External medullary lamina


Enthorinal cortex




Forceps minor of the corpus callosum


Forceps major of the corpus callosum


Fasciculus retroflexus


Gigantocellular reticular N, alpha part


Gigantocellular reticular N, ventral part


Globus pallidus


Diagonal band of Broca, horizontal limb


Interanterodorsal thalamic N


Interanteromedial thalamic N


Internal capsule


Intermediodorsal thalamic N


Intermediate gray layer of the superior colliculus


Intermediate white layer of the superior colliculus


Interpedoncular N


Lateral accumbens, shell region


Locus coeruleus


Laterodorsal thalamic N


LD, dorsomedial part


Laterodorsal tegmental N


LD, ventrolateral part


Lateral hypothalamic area


Lateral habenula


Lateral orbital cortex


Lateral posterior thalamic N


Lateral posterior thalamic N, laterorostral part


Lateral posterior thalamic N, mediorostral part


Lateral preoptic area


Lateral septal N, intermediate part


Lateral ventricle


Secondary motor cortex


Mammillary bodies


Midcingulate cortex


Mediodorsal thalamic N


Mediodorsal thalamic N, central part


Mediodorsal thalamic N, lateral part


Mediodorsal thalamic N, medial part


Mesencephalic trigeminal tract


Medial habenular N


Median raphe N


Medial orbital cortex


Medial pretectal N


Mesencephalic reticular formation


Medial septal N


Mamillotegmental tract




Optic nerve layer of the superior colliculus


Optic tract


Parafascicular thalamic N


Periaqueductal gray


Periaqueductal gray, dorsolateral part


Periaqueductal gray, dorsomedial part


Periaqueductal gray, lateral part


Periaqueductal gray, ventrolateral part


Periaqueductal gray, rostral part


Paracentral thalamic N


Posterior hypothalamic N


Principal mammillary tract


Paramedian raphe N


Pontine N


Pontine reticular N, caudal part


Pontine reticular N, oral part


Posterior thalamic N group




Precuneiform area


Pregeniculate N of the prethalamus


Prerubral field


Perirhinal cortex


Paratenial thalamic N


Parietal associative cortex


Pedunculotegmental N


Paraventricular thalamic N


Hypothalamic paraventricular N


Pyramidal tract


Reuniens thalamic N


Rhomboid thalamic N


Raphe interpositus N


Retromamillary N


Raphe magnus N


Raphe pallidus N


Retrosplenial cortex


Reticular N


Ventromedial medulla region


Primary somatosensory cortex


Superior colliculus


Superior cerebellar peduncle


Stria medullaris


Substantia nigra, pars compacta


Substantia nigra, pars reticulata


Stria terminalis


Subthalamic N


Submedius N


Superficial gray layer of the superior colliculus


Temporal association cortex


Tectospinal tract


Olfactory tubercle


Primary visual cortex


Secondary visual cortex, lateral area


Secondary visual cortex, medial area


Secondary visual cortex, mediolateral area


Secondary visual cortex, mediomedial area


Ventral anterior thalamic N


Diagonal band of Broca, vertical limb


Ventrolateral thalamic N


Ventromedial thalamic N


Ventral orbital cortex


Ventral pallidum


Ventral posterolateral thalamic N


Ventral posteromedial thalamic N


Ventral tegmental area


Ventral tegmental N


Zona incerta


ZI, dorsal part


ZI, rostral part


ZI, ventral part



We thank the Chronobiotron (UMS3415) for animal housing and animal care. This work was supported by the Centre National de la Recherche Scientifique (contract UPR3212), the University of Strasbourg and by a NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation.

Compliance with ethical standards

Ethical standards

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

Informed consent

No human subject were used in this study.

Conflict of interest

The authors declare that they have no conflict of interest.


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© Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Institut des Neurosciences Cellulaires et IntégrativesCentre National de la Recherche Scientifique, CNRS UPR3212StrasbourgFrance
  2. 2.Université de StrasbourgStrasbourgFrance

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