Abstract
We report the unusual occurrence of Kaposi’s sarcoma following asbestos-related malignant mesothelioma, in a human deficiency virus (HIV)-negative Italian man. Seropositivity to human herpes virus 8 (HHV8) was documented at the time of mesothelioma diagnosis and preceded the onset of Kaposi’ sarcoma with a time lapse of 13 months. HHV8 DNA was detected by polymerase chain reaction in lesional Kaposi’s sarcoma but not within mesothelioma. By immunostaining, mesothelioma cells expressed interleukin-6 and platelet-derived growth factor, which are important for survival of Kaposi’s sarcoma cells. Besides the possibility of a casual association, we hypothesize that mesothelioma-linked factors may have contributed to the development of Kaposi’sarcoma in the presence of HHV8 infection.
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Received: 12 April 1999 / Accepted: 24 June 1999
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Ascoli, V., Carnovale Scalzo, C., Andreoni, M. et al. Kaposi’s sarcoma following malignant mesothelioma. Virchows Archiv 435, 612–615 (1999). https://doi.org/10.1007/s004280050448
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DOI: https://doi.org/10.1007/s004280050448