Histiocyte-rich rhabdomyoblastic tumor: a report of two cases and a review of the differential diagnoses


Histiocyte-rich rhabdomyoblastic tumor is a recently described skeletal muscle neoplasm of uncertain malignant potential, characterized by slow growth, a fibrous capsule containing peripheral lymphoid aggregates, spindle-to-epithelioid cells with a rhabdomyoblastic immunophenotype, and a dense histiocytic infiltrate. It most commonly arises within the muscles of the lower legs and trunk in young-to-middle–aged men, and initial reports suggest indolent behavior. In this paper, we present two additional cases of histiocyte-rich rhabdomyoblastic tumor with similar clinicopathologic features and discuss the differential diagnosis including its overlap with inflammatory leiomyosarcoma.

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Melanie Bourgeau: wrote the manuscript, composed figures, and edited the manuscript.

Anthony P. Martinez: edited the manuscript, edited the figures and composed the table.

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Correspondence to Anthony P. Martinez.

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The original version of this article was revised: The family name of the co-author of the article mentioned above was incorrectly spelled. The correct name should have been “Melanie Bourgeau” instead of “Melanine Bourgeau”. The has been corrected.

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Bourgeau, M., Martinez, A.P. Histiocyte-rich rhabdomyoblastic tumor: a report of two cases and a review of the differential diagnoses. Virchows Arch (2020). https://doi.org/10.1007/s00428-020-02857-x

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  • Histiocyte-rich rhabdomyoblastic tumor
  • Inflammatory leiomyosarcoma
  • Rhabdomyosarcoma
  • MyoD1
  • Smooth muscle tumors
  • Rhabdomyoma