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Hormonal receptors in cutaneous vascular malformations: 51 cases

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A Correction to this article was published on 19 March 2019

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Abstract

Vascular malformations (VMs) are rare congenital anomalies that develop during embryogenesis in different types of vessels. Several triggering factors of cutaneous VMs include trauma, infections, or hormonal changes. We investigated the expression of hormonal receptors (androgen, estrogen, progesterone) in tissue samples of well-characterized VMs. A secondary objective was to identify self-reported triggering factors for these VMs, including hormonal changes, in the cohort of patients. We included patients with VM samples obtained in the tertiary center for vascular anomalies of the University Hospital Center of Tours, France, from January 1, 2007, to August 1, 2018. Immunohistochemistry was used to detect the expression of hormonal receptors (estrogen, progesterone, androgens). We obtained 51 samples from 51 patients: 13 cystic lymphatic malformations (CLMs), 16 venous malformations (VeMs), 11 arteriovenous malformations (AVMs), 4 combined VMs, 4 PIK3CA-related overgrowth spectrum, 1 Parkes-Weber syndrome, 1 Gorham syndrome, and 1 multiple lymphangioendotheliomatosis with thrombopenia. In total, 38 (74.5%) samples were positive for androgen receptor: 11 (84.6%) CLMs, 12 (75.0%) VeMs, 8 (72.2%) AVMs, and 7/11 (63.5%) other samples. All samples were negative for estrogen and progesterone receptors. Triggering factors were self-reported in 7 cases and were most frequently hormonal changes (n = 6, 18.2%). Hormonal triggers were frequent in AVMs (n = 4). Among patients with identified hormonal triggers, VM samples were positive for androgen receptor in 3 and negative in 3. Three-quarters of our VM samples expressed androgen receptor, and most CLM, VeM, and AVM samples were positive. Hormonal triggers were identified in 6/33 patients, mostly with AVMs.

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Change history

  • 19 March 2019

    The original version of this article contained error. Table 2 was shown in the wrong version, thus corrected table is shown in this article.

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Acknowledgements

We thank Dr. M. Dorbeau for the H&E images.

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Authors and Affiliations

  1. University of Tours, 37000, Tours, France

    Sarah Ventéjou, M.-C. Machet, D. Herbreteau, G. Lorette & A. Maruani

  2. Department of Dermatology, University Hospital Center (CHRU) of Tours, Avenue de la République, 37044, Tours CEDEX 9, France

    Sarah Ventéjou, G. Lorette & A. Maruani

  3. Department of Pathology, University Hospital Center (CHRU) of Tours, 37000, Tours, France

    M.-C. Machet

  4. Department of Neuroradiology, University Hospital Center (CHRU) of Tours, 37000, Tours, France

    D. Herbreteau

  5. Reference Center for Rare Dermatologic Diseases (MAGEC) - Vascular Malformations and Mosaicism, CHRU Tours, 37000, Tours, France

    D. Herbreteau, A. le Touze, G. Lorette & A. Maruani

  6. Department of Pediatric Surgery, University Hospital Center (CHRU) of Tours, 37000, Tours, France

    A. le Touze

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  1. Sarah Ventéjou
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The original version of this article was revised: Table 2 was shown in the wrong version, thus corrected table is shown in this article.

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Ventéjou, S., Machet, MC., Herbreteau, D. et al. Hormonal receptors in cutaneous vascular malformations: 51 cases. Virchows Arch 474, 755–761 (2019). https://doi.org/10.1007/s00428-019-02546-4

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