Abstract
Metaplastic ossification within the lung is seen in a variety of diseases, usually as sequela of either a separate primary pulmonary parenchymal disease or an underlying cardiac disorder such as valvular disease. Primary intraalveolar ossification or ossification within the alveolar septa is a rare entity. Similarly, it is unusual to see overt, diffuse disease affecting the lung to the point of respiratory failure leading to lung transplant. We present a case of an adult male who underwent bilateral lung transplantation, with the native lung pathology showing diffuse, severe dendriform ossification of the bilateral upper and lower lung lobes. The gross and histologic findings along with the radiographic imaging are reviewed herein. Overall, primary ossification of the lung leading to lung transplant is a rare condition that pulmonologists caring for patients with interstitial lung disease should be aware of as a possible cause of the patient’s symptoms and lung dysfunction.
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References
Nicholson AG, Rice AJ (2013) In: Hasleton P, Flieder DB (eds) Interstitial lung diseases in Spencer’s pathology of the lung. Cambridge University Press, Cambridge, pp 392–393
Joines RW, Roggli VL (1989) Dendriform pulmonary ossification. Report of two cases with unique findings. Am J Clin Pathol 91(4):398–402
Kanne JP et al (2004) Diffuse pulmonary ossification. J Thorac Imaging 19(2):98–102
Lara JF et al (2005) Dendriform pulmonary ossification, a form of diffuse pulmonary ossification: report of a 26-year autopsy experience. Arch Pathol Lab Med 129(3):348–353
Pracyk JB et al (1996) Composition of lung lavage in pulmonary alveolar microlithiasis. Respiration 63(4):254–260
Chan ED et al (2002) Calcium deposition with or without bone formation in the lung. Am J Respir Crit Care Med 165(12):1654–1669
Bisceglia M et al (2015) Selected case from the Arkadi M. Rywlin international pathology slide series: diffuse dendriform pulmonary ossification: report of 2 cases with review of the literature. Adv Anat Pathol 22(1):59–68
Fernandez-Bussy S et al (2015) Dendriform pulmonary ossification. Respir Care 60(4):e64–e67
Peros-Golubicic T, Tekavec-Trkanjec J (2008) Diffuse pulmonary ossification: an unusual interstitial lung disease. Curr Opin Pulm Med 14(5):488–492
Tseung J, Duflou J (2006) Diffuse pulmonary ossification: an uncommon incidental autopsy finding. Pathology 38(1):45–48
Kim DU, Guinee D, Mohammed TL (2015) Case of the season: usual interstitial pneumonia with dendriform pulmonary ossification. Semin Roentgenol 50(1):4–7
Kim TS et al (2005) Disseminated dendriform pulmonary ossification associated with usual interstitial pneumonia: incidence and thin-section CT-pathologic correlation. Eur Radiol 15(8):1581–1585
Konoglou M et al (2013) Lung ossification: an orphan disease. JTD 5(1):101–104
Reinehr M et al (2003) Diffuse pulmonary ossifications with mortal consequences. A case report. Pathologe 24(2):114–118
Gevenois PA et al (1994) Disseminated pulmonary ossification in end-stage pulmonary fibrosis: CT demonstration. AJR Am J Roentgenol 162(6):1303–1304
Jamjoom L, Meziane M, Renapurkar RD (2013) Dendriform pulmonary ossification: report of two cases. IJRI 23(1):15–18
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The current study was submitted and approved by the Duke Institutional Review Board for Clinical Investigations.
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Carney, J.M., Mammarappallil, J.G., Sporn, T.A. et al. Dendriform pulmonary ossification leading to bilateral lung transplant: a case report. Virchows Arch 473, 379–383 (2018). https://doi.org/10.1007/s00428-018-2412-3
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DOI: https://doi.org/10.1007/s00428-018-2412-3