Dual JAK1 and STAT3 mutations in a breast implant-associated anaplastic large cell lymphoma

  • Audrey Letourneau
  • Marie Maerevoet
  • Dina Milowich
  • Roland Dewind
  • Bettina Bisig
  • Edoardo Missiaglia
  • Laurence de Leval
Brief Report


Breast implant-associated anaplastic large cell lymphoma (BI-ALCL), recently described as a distinctive form of CD30+ anaplastic large cell lymphoproliferation, was introduced as a new provisional T cell lymphoma entity in the 2017 WHO classification of hematological malignancies [1]. While the morphological and immunophenotypical features of BI-ALCL are indistinguishable from those of other ALK-negative ALCL, the specificity of BI-ALCL is its clinical presentation adjacent to a breast implant. Most cases confined to the periprosthetic effusion and capsule (seroma or “in situ” lymphoma) have excellent outcomes, and a minority of patients present with a breast tumor mass, which is an adverse prognostic factor [2, 3].

Yet, information on the genetic alterations associated with BI-ALCL is essentially limited to data derived from a few lymphoma specimens, all with seroma-associated presentation (summarized in Table 1) [ 4, 5, 6, 7]. Here, we report genetic findings in paired...


Author contributions

AL and DM performed research; MM and RD contributed essential clinical information; BB and EM analyzed the data and wrote the paper; LDL designed research and wrote the paper.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Institute of PathologyLausanne University Hospital (CHUV)LausanneSwitzerland
  2. 2.Department of HaematologyInstitut Jules BordetBrusselsBelgium
  3. 3.Department of PathologyInstitut Jules BordetBrusselsBelgium

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