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Handling and reporting of transperineal template prostate biopsy in Europe: a web-based survey by the European Network of Uropathology (ENUP)

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Abstract

Transperineal template prostate biopsies (TTPB) are performed for assessments after unexpected negative transrectal ultrasound biopsies (TRUSB), correlation with imaging findings and during active surveillance. The impact of TTPBs on pathology has not been analysed. The European Network of Uropathology (ENUP) distributed a survey on TTPB, including how specimens were received, processed and analysed. Two hundred forty-four replies were received from 22 countries with TTPBs seen by 68.4% of the responders (n = 167). Biopsies were received in more than 12 pots in 35.2%. The number of cores embedded per cassette varied between 1 (39.5%) and 3 or more (39.5%). Three levels were cut in 48.3%, between 2 and 3 serial sections in 57.2% and unstained spare sections in 45.1%. No statistical difference was observed with TRUSB management. The number of positive cores was always reported and the majority gave extent per core (82.3%), per region (67.1%) and greatest involvement per core (69.4%). Total involvement in the whole series and continuous/discontinuous infiltrates were reported in 42.2 and 45.4%, respectively. The majority (79.4%) reported Gleason score in each site or core, and 59.6% gave an overall score. A minority (28.5%) provided a map or a diagram. For 19%, TTPB had adversely affected laboratory workload with only 27% managing to negotiate extra costs. Most laboratories process samples thoroughly and report TTPB similarly to TRUSB. Although TTPB have caused considerable extra work, it remains uncosted in most centres. Guidance is needed for workload impact and minimum standards of processing if TTPB work continues to increase.

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Acknowledgements

We would like to thank all ENUP members for their support and for taking the time to participate in the survey. DB is supported by Orchid.

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Authors and Affiliations

  1. Barts Cancer University-Queen Mary University, Charterhouse square, EC1M, London, 6BQ, UK

    Solene-Florence Kammerer-Jacquet & Daniel M. Berney

  2. Service d’Anatomie et Cytologie Pathologiques, Université de Rennes 1, Université Bretagne Loire, 35042, Rennes, France

    Solene-Florence Kammerer-Jacquet

  3. Hôpital Tenon, HUEP, AP-HP, Université la Sorbonne, Paris, France

    Eva Compérat

  4. Karolinska Institutet, Stockholm, Sweden

    Lars Egevad

  5. Charles University, Pilsen, Czech Republic

    Ondra Hes

  6. North Bristol NHS Trust, Bristol, UK

    Jon Oxley

  7. University Hospital of Wales, Cardiff, UK

    Murali Varma

  8. University of Bonn, Bonn, Germany

    Glen Kristiansen

Authors
  1. Solene-Florence Kammerer-Jacquet
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  2. Eva Compérat
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  3. Lars Egevad
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  4. Ondra Hes
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  6. Murali Varma
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  7. Glen Kristiansen
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  8. Daniel M. Berney
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Contributions

The survey was conceived by DB. All authors contributed to the design of the survey. GK uploaded the survey on Survey Monkey. GK circulated the survey invitation email and reminders. The data was cleaned and analysed by GK, SFKJ and DB. The paper was drafted by SFKJ and DB. All authors contributed to revising the draft paper and are guarantors for this publication.

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Correspondence to Solene-Florence Kammerer-Jacquet.

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We confirm that this work is original and has neither been published elsewhere nor is currently under consideration for publication elsewhere. All authors have read and approved the manuscript.

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Institutional ethical guidelines were followed for this study.

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The authors of this article have no relevant financial relationships with commercial interests to disclose.

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Kammerer-Jacquet, SF., Compérat, E., Egevad, L. et al. Handling and reporting of transperineal template prostate biopsy in Europe: a web-based survey by the European Network of Uropathology (ENUP). Virchows Arch 472, 599–604 (2018). https://doi.org/10.1007/s00428-017-2265-1

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  • DOI: https://doi.org/10.1007/s00428-017-2265-1

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