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Molecular heterogeneity characterizes glioblastoma with lipoblast/adipocyte-like cytology

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Abstract

Glioblastoma, the most common primary brain tumor in adults, may rarely show among unusual histological patterns lipoblast/adipocyte-like features. The genetic features of such cases are not yet well characterized, and molecular data are available for only few cases. In order to further expand our knowledge about their molecular profile, we analyzed four cases of glioblastoma with adipocyte-like features. Multiplex ligation-dependent probe amplification (MLPA) revealed loss of PTEN and MDM2 amplification in two cases while another case was characterized by CDKN2A deletion. Conversely, we did not find any evidence of EGFR amplification, BRAF V600E or IDH1/2 mutations. Our results, along with data published in previous studies, showed that glioblastoma with lipoblast/adipocyte-like cytology present a heterogeneous genetic background and therefore seem to represent more a rare phenotypic variant than a specific tumor subtype.

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Conflict of interest

All authors declare no conflict of interest.

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Authors and Affiliations

  1. Institute of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Straße 25, 53127, Bonn, Germany

    Marco Gessi, Gerrit H. Gielen, Dorota Denkhaus, Anja zur Mühlen, Anna Sophia Japp & Torsten Pietsch

  2. Department of Pathology, University of Rome, “La Sapienza”, Rome, Italy

    Manila Antonelli & Felice Giangaspero

  3. IRCCS Neuromed, Pozzilli, IS, Italy

    Felice Giangaspero

Authors
  1. Marco Gessi
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  2. Gerrit H. Gielen
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  3. Dorota Denkhaus
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  4. Manila Antonelli
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  5. Felice Giangaspero
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  6. Anja zur Mühlen
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  7. Anna Sophia Japp
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  8. Torsten Pietsch
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Correspondence to Marco Gessi.

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Gessi, M., Gielen, G.H., Denkhaus, D. et al. Molecular heterogeneity characterizes glioblastoma with lipoblast/adipocyte-like cytology. Virchows Arch 467, 105–109 (2015). https://doi.org/10.1007/s00428-015-1774-z

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  • DOI: https://doi.org/10.1007/s00428-015-1774-z

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