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Hibernoma-like brown fat in the bone marrow: report of a unique case

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Abstract

We report on a bone-marrow biopsy of a 61-year-old female patient that was performed because of the clinical suspicion of a myeloproliferative disease. The trephine biopsy showed morphological features that were consistent with an essential thrombocythaemia (ET). The diagnosis of a myeloproliferative disease could be corroborated by demonstration of the V617F mutation of JAK2. Besides the histological features of ET, the marrow showed a peculiar infiltrate that consisted of multivacuolated cells that were immunohistochemically identified as brown adipose tissue with a hibernoma-like picture. To the best of our knowledge, this is the first report on brown adipose tissue in the bone marrow.

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Authors and Affiliations

  1. Institut für Pathologie und Konsultations-und Referenzzentrum für Lymphknotendiagnostik und Hämatopathologie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany

    C. Thorns, C. Kähler, H. Merz & A. C. Feller

  2. Onkologische Schwerpunktpraxis, Gelsenkirchen, Germany

    C. Schardt

  3. Institut für Pathologie und Konsultations-und Referenzzentrum für Weichgewebstumoren, Universitätsklinikum Jena, Jena, Germany

    D. Katenkamp

Authors
  1. C. Thorns
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  2. C. Schardt
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  3. D. Katenkamp
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  4. C. Kähler
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  5. H. Merz
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  6. A. C. Feller
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Correspondence to C. Thorns.

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Thorns, C., Schardt, C., Katenkamp, D. et al. Hibernoma-like brown fat in the bone marrow: report of a unique case. Virchows Arch 452, 343–345 (2008). https://doi.org/10.1007/s00428-007-0559-4

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  • DOI: https://doi.org/10.1007/s00428-007-0559-4

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