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Electrophysiology of the pancreatic islet β-cell sweet taste receptor TIR3

  • Signaling and cell physiology
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Abstract

Over recent years, the presence of the sweet taste receptor TIR3 in rodent and human insulin-producing pancreatic islet β-cells was documented. The activation of this receptor by sweet-tasting sucralose mimics several biochemical and functional effects of d-glucose in the β-cells. The present study extends this analogy to the bioelectrical response of β-cells. In this respect, sucralose was inefficient in the absence of d-glucose, but induced on occasion electrical activity in mouse β-cells exposed to low non-stimulatory concentrations of the hexose and potentiated, in a concentration-related manner, the response to stimulatory concentrations of d-glucose. These data indicate that sucralose, acting as an agonist of the TIR3 receptor, exerts an excitatory effect upon pancreatic β-cell bioelectrical activity.

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Authors and Affiliations

  1. Department of Medicine, Universitat Jaume 1, Castellon, Spain

    Juan V. Sanchez-Andres

  2. Department of Biochemistry, Université Libre de Bruxelles, Brussels, Belgium

    Willy J. Malaisse

  3. Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan

    Itaru Kojima

Authors
  1. Juan V. Sanchez-Andres
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  2. Willy J. Malaisse
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  3. Itaru Kojima
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Correspondence to Juan V. Sanchez-Andres.

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Sanchez-Andres, J.V., Malaisse, W.J. & Kojima, I. Electrophysiology of the pancreatic islet β-cell sweet taste receptor TIR3. Pflugers Arch - Eur J Physiol 471, 647–654 (2019). https://doi.org/10.1007/s00424-018-2237-6

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  • DOI: https://doi.org/10.1007/s00424-018-2237-6

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