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Pflügers Archiv - European Journal of Physiology

, Volume 470, Issue 2, pp 263–275 | Cite as

Resistance exercise improves cardiac function and mitochondrial efficiency in diabetic rat hearts

  • Tae Hee Ko
  • Jubert C. Marquez
  • Hyoung Kyu Kim
  • Seung Hun Jeong
  • SungRyul Lee
  • Jae Boum Youm
  • In Sung Song
  • Dae Yun Seo
  • Hye Jin Kim
  • Du Nam Won
  • Kyoung Im Cho
  • Mun Gi Choi
  • Byoung Doo Rhee
  • Kyung Soo Ko
  • Nari Kim
  • Jong Chul WonEmail author
  • Jin HanEmail author
Integrative Physiology
Part of the following topical collections:
  1. Integrative Physiology

Abstract

Metabolic disturbance and mitochondrial dysfunction are a hallmark of diabetic cardiomyopathy (DC). Resistance exercise (RE) not only enhances the condition of healthy individuals but could also improve the status of those with disease. However, the beneficial effects of RE in the prevention of DC and mitochondrial dysfunction are uncertain. Therefore, this study investigated whether RE attenuates DC by improving mitochondrial function using an in vivo rat model of diabetes. Fourteen Otsuka Long-Evans Tokushima Fatty rats were assigned to sedentary control (SC, n = 7) and RE (n = 7) groups at 28 weeks of age. Long-Evans Tokushima Otsuka rats were used as the non-diabetic control. The RE rats were trained by 20 repetitions of climbing a ladder 5 days per week. RE rats exhibited higher glucose uptake and lower lipid profiles, indicating changes in energy metabolism. RE rats significantly increased the ejection fraction and fractional shortening compared with the SC rats. Isolated mitochondria in RE rats showed increase in mitochondrial numbers, which were accompanied by higher expression of mitochondrial biogenesis proteins such as proliferator-activated receptor-γ coactivator-1α and TFAM. Moreover, RE rats reduced proton leakage and reactive oxygen species production, with higher membrane potential. These results were accompanied by higher superoxide dismutase 2 and lower uncoupling protein 2 (UCP2) and UCP3 levels in RE rats. These data suggest that RE is effective at ameliorating DC by improving mitochondrial function, which may contribute to the maintenance of diabetic cardiac contractility.

Keywords

Diabetic cardiomyopathy Resistance exercise Cardiac function Mitochondrial function 

Notes

Funding information

This work was supported by the grant from the Priority Research Centers Program and Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science, and Technology (NRF-2010-0020224, NRF-2015R1A2A1A13001900) and Korean Diabetes Association (J.C.W., 2015F2). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Compliance with ethical standards

All experimental procedures were approved by the Institutional Review Board of Animals, Inje University College of Medicine (approval number: 2011-049).

Supplementary material

424_2017_2076_MOESM1_ESM.docx (78 kb)
ESM 1 (DOCX 77 kb)

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Tae Hee Ko
    • 1
  • Jubert C. Marquez
    • 1
  • Hyoung Kyu Kim
    • 1
    • 2
  • Seung Hun Jeong
    • 1
  • SungRyul Lee
    • 1
    • 2
  • Jae Boum Youm
    • 1
  • In Sung Song
    • 1
  • Dae Yun Seo
    • 1
  • Hye Jin Kim
    • 3
  • Du Nam Won
    • 3
  • Kyoung Im Cho
    • 4
  • Mun Gi Choi
    • 5
  • Byoung Doo Rhee
    • 6
  • Kyung Soo Ko
    • 6
  • Nari Kim
    • 1
  • Jong Chul Won
    • 6
    Email author
  • Jin Han
    • 1
    Email author
  1. 1.National Research Laboratory for Mitochondrial Signaling, Department of Physiology, Department of Health Sciences and Technology, BK21 plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease CenterInje UniversityBusanRepublic of Korea
  2. 2.Department of Integrated Biomedical Science, College of MedicineInje UniversityBusanRepublic of Korea
  3. 3.GE Healthcare Ultrasound ApplicationsBusanRepublic of Korea
  4. 4.Division of Cardiology, Department of Internal Medicine, College of MedicineKosin UniversityBusanRepublic of Korea
  5. 5.Departments of Sports and Leisure StudyInje UniversityGimhaeRepublic of Korea
  6. 6.Department of Internal Medicine, College of Medicine, Sanggye Paik Hospital, Cardiovascular and Metabolic Disease CenterInje UniversitySeoulRepublic of Korea

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