European Journal of Applied Physiology

, Volume 118, Issue 5, pp 1021–1031 | Cite as

The acute effect of Quercetin on muscle performance following a single resistance training session

  • Federica Patrizio
  • Massimiliano Ditroilo
  • Francesco Felici
  • Guglielmo Duranti
  • Giuseppe De Vito
  • Stefania Sabatini
  • Massimo Sacchetti
  • Ilenia Bazzucchi
Original Article



To examine the effect of acute quercetin (Q) ingestion on neuromuscular function, biomarkers of muscle damage, and rate of perceived exertion (RPE) in response to an acute bout of resistance training.


10 young men (22.1 ± 1.8 years, 24.1 ± 3.1 BMI) participated in a randomized, double-blind, crossover study. Subjects consumed Q (1 g/day) or placebo (PLA) 3 h prior to a resistance training session which consisted of 3 sets of 8 repetitions at 80% of the one repetition maximum (1RM) completed bilaterally for eight different resistance exercises. Electromyographic (EMG) signals were recorded from the knee extensor muscles during maximal isometric (MVIC) and isokinetic voluntary contractions, and during an isometric fatiguing test. Mechanical and EMG signals, biomarkers of cell damage, and RPE score were measured PRE, immediately POST, and 24 h (blood indices only) following the resistance exercise.


After a single dose of Q, the torque–velocity curve of knee extensors was enhanced and after the resistance exercise, subjects showed a lower MVIC reduction (Q: 0.91 ± 6.10%, PLA: 8.66 ± 5.08%) with a greater rate of torque development (+ 10.6%, p < 0.005) and neuromuscular efficiency ratio (+ 28.2%, p < 0.005). Total volume of the resistance exercises was significantly greater in Q (1691.10 ± 376.71 kg rep) compared to PLA (1663.65 ± 378.85 kg rep) (p < 0.05) with a comparable RPE score. No significant differences were found in blood marker between treatments.


The acute ingestion of Q may enhance the neuromuscular performance during and after a resistance training session.


Flavonoids Strength Electromyography Muscle damage 



Analysis of variance


Biceps femoris


Body mass index


Coactivation index


Creatine kinase




Glutathione status


Oxidized gluthanione


Intraclass correlation coefficients


Isometric fatiguing test


Median frequency


Maximal voluntary isometric contraction


Neuromuscular efficiency




Perceived recovery scale




Rectus femoris


Root mean square


Rate of perceived exertion


Rate of torque development


Visual analogue scale


One repetition maximum


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Laboratory of Exercise Physiology, Department of Movement, Human and Health SciencesUniversità degli Studi di Roma “Foro Italico”RomaItaly
  2. 2.School of Public Health, Physiotherapy and Sports Science, Institute of Sport and HealthUniversity College DublinDublin 4Ireland
  3. 3.Laboratory of Biochemistry of Movement, Department of Movement, Human and Health SciencesUniversità degli Studi di Roma “Foro Italico”RomaItaly

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