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Joint association of carrying HLA-B*13:01 gene and human herpesvirus-6 with occupational trichloroethylene hypersensitivity syndrome

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International Archives of Occupational and Environmental Health Aims and scope Submit manuscript

Abstract

Purpose

Occupational trichloroethylene hypersensitivity syndrome (OTHS) clinically manifests as generalized severe rash resembling drug-induced hypersensitivity syndrome (DIHS) and afflicts predominantly HLA-B*13:01 gene carriers after their exposure to trichloroethylene. Meanwhile, OTHS may also be associated with human herpesvirus such as herpesvirus-6 (HHV6) and cytomegalovirus (HCMV) reported to participate in the pathology of DIHS. This study explored the association of carrying HHV6 and HCMV, and the joint association of carrying HLA-B*13:01 and HHV6 and HCMV with OTHS.

Methods

We recruited 30 OTHS patients and 40 trichloroethylene-exposed healthy workers as cases and controls, respectively. HLA-B*13:01 was genotyped and HHV6 and HCMV DNA were detected in the DNA extracted from whole-blood sample of each participant with PCR techniques. Positive rates of HLA-B*13:01 gene and HHV6 and HCMV DNA and their association with OTHS were then analyzed.

Results

The OTHS cases showed significantly higher positive rates of HLA-B*13:01 gene and HHV6 DNA, but not HCMV DNA, than the controls (83.3% vs. 25.0% and 56.7% vs. 10.0%, respectively, both P < 0.001). Positive rate of HHV6 DNA was significantly higher in HLA-B*13:01 carriers than in non-carriers in the cases (68.0% vs. 0, P = 0.005), but not in the controls. Carrying HLA-B*13:01 and HHV6 had an interactive effect on OTHS (OR = 91.80, P < 0.001).

Conclusions

Carrying HLA-B*13:01 and HHV6 may be associated with OTHS; furthermore, carrying HLA-B*13:01 and HHV6 may be jointly associated with OTHS.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (no. 81502797) and the Discipline Layout Project of Shenzhen Science and Technology Innovation Committee (no. JCYJ20160429090813380).

Funding

This study was funded by the National Natural Science Foundation of China (no. 81502797) and the Discipline Layout Project of Shenzhen Science and Technology Innovation Committee (no. JCYJ20160429090813380).

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Author notes

  1. Dianpeng Wang and Dafeng Lin contributed equally to this work.

Authors and Affiliations

  1. Clinical Laboratory, Shenzhen Prevention and Treatment Center for Occupational Diseases, 2019 Buxin Rd., Luohu District, Shenzhen, 518020, China

    Dianpeng Wang, Dafeng Lin, Peimao Li, Zhimin Zhang & Yanfang Zhang

  2. Poisoning Detection Center, Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen, China

    Dianpeng Wang, Dafeng Lin, Peimao Li, Zhimin Zhang, Yanfang Zhang & Xianqing Huang

  3. Hebei North University, Hebei, China

    Huimin Liu, Yanhua Yang & Qiuyue Kong

Authors
  1. Dianpeng Wang
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  2. Dafeng Lin
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  4. Huimin Liu
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Correspondence to Dafeng Lin.

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The authors declare that they have no conflict of interest.

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Informed consent was obtained from all individual participants included in the study.

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All procedures performed in the study involving human participants were in accordance with the ethical standards of the Ethics Committee of Shenzhen Prevention and Treatment Center for Occupational Diseases and with the 1975 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Wang, D., Lin, D., Li, P. et al. Joint association of carrying HLA-B*13:01 gene and human herpesvirus-6 with occupational trichloroethylene hypersensitivity syndrome. Int Arch Occup Environ Health 92, 395–401 (2019). https://doi.org/10.1007/s00420-019-01417-4

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