Abstract
Even though the majority of knowledge about phospholipids comes from their cytoplasmic functions, in the last decade, it has been shown that nuclear phospholipids and their building blocks, inositol phosphates, have many important roles in the cell nucleus. There are clear connections of phospholipids with the regulation of gene expression and chromatin biology, however, this review focuses on less known functions of nuclear phospholipids in connection with the epigenome regulation. In particular, we highlight the roles of nuclear phospholipids and inositol phosphates that involve histone modifications, such as acetylation or methylation, tightly connected with the cell physiology. This demonstrates the importance of nuclear phospholipids in the regulation of cellular processes, and should encourage further research of nuclear phospholipids and inositol phosphates.
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Acknowledgements
This work was supported by the Grant Agency of the Czech Republic (Grant nos. 15-08738S; 16-03346S and 17-09103S); by the Czech Academy of Sciences (Grant no. JSPS-18-18) and the Institutional Research Concept of the Institute of Molecular Genetics (Grant no. RVO: 68378050). This work was supported by the project “BIOCEV—Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University” (CZ.1.05/1.1.00/02.0109), from the European Regional Development Fund. This work was supported by the Microscopy Centre; Light/Electron CF, IMG CAS supported by the MEYS CR (LM2015062 Czech-BioImaging). The work is supported from European Regional Development Fund-Project “Modernization and support of research activities of the national infrastructure for biological and medical imaging Czech-BioImaging” (no. CZ.02.1.01/0.0/0.0/16_013/0001775).
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Uličná, L., Paprčková, D., Fáberová, V. et al. Phospholipids and inositol phosphates linked to the epigenome. Histochem Cell Biol 150, 245–253 (2018). https://doi.org/10.1007/s00418-018-1690-9
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DOI: https://doi.org/10.1007/s00418-018-1690-9