A novel EyePhone© App for improving adherence to glaucoma therapy



Despite advances in glaucoma treatment options, patient adherence and compliance remain very low. The EyePhone© App is a free non-commercial reminder application designed specifically for the needs of glaucoma patients. In this study, we evaluated its usefulness in improving adherence to medical treatment among glaucoma patients.


This is a prospective multicenter interventional study. Glaucoma patients were recruited from a tertiary center and a large community glaucoma service center. After a short explanation, the EyePhone© App was installed on their smartphone device, and the notifications for the current medical treatment were entered. After enrollment and at 1-month follow-up, subjects completed the Morisky Medication Adherence Scale (MMAS-8) and the Quality of Life and Glaucoma 17-item (GlauQOL-17) questionnaires for evaluation of adherence and QOL, respectively.


In the study, 133 patients (71 men and 62 women) aged 62±15.5 years and using 2.0±0.9 IOP-lowering drugs participated. The proportion of highly adherent subjects improved from 29.3% (39/133) at baseline to 42.1% (56/133) at follow-up (P < 0.001), and the proportion of poorly adherent subjects decreased from 29.3 (39/133) to 20.3% (27/133) at follow-up (P = 0.012). QOL also improved, as evidenced by a significant increase in the GlauQOL-17 score (P < 0.05). In a subgroup of patients for whom IOP measurements were available, IOP reduced by 0.92 mmHg (P = 0.069).


Significant improvements in glaucoma adherence and QOL were achieved among poorly adherent glaucoma patients after 1 month of using the EyePhone© App.

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Data availability

Upon request.

Code availability

The EyePhone® App is available for download without charge from the Google Play app store: https://play.google.com/store/apps/details?id=com.glaoucmaskaatleshno.drugreminder2


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Corresponding author

Correspondence to Ari Leshno.

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Ethics approval

The study was approved by both the Sheba Medical Center and the “Clalit” healthcare services institutional review boards.

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All participants signed an informed consent form

Conflict of interest

Two of the authors (AL and AS) developed the EyePhone® App. The other authors declare no competing interests.

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Leshno, A., Gaton, D., Singer, R. et al. A novel EyePhone© App for improving adherence to glaucoma therapy. Graefes Arch Clin Exp Ophthalmol (2021). https://doi.org/10.1007/s00417-021-05091-6

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  • Glaucoma
  • Adherence
  • Quality of life
  • Smartphone
  • Application