Visual outcome and poor prognostic factors in acute retinal necrosis syndrome

A Correction to this article was published on 25 August 2020

This article has been updated



To evaluate the impact of selected clinical parameters on the mid-/long-term visual outcome of patients with acute retinal necrosis (ARN)


A retrospective cohort study



Two University Hospitals (Parma, Italy; Lausanne, Switzerland).


Thirty-nine non-HIV patients (39 eyes) with ARN, as confirmed by polymerase chain reaction on intraocular samples. The following potential predictors were tested using linear regression models: age, sex, etiology, best-corrected visual acuity (BCVA) on admission, delay between ARN symptom onset and treatment initiation, and surgery (performed or not).

Main outcome

BCVA at the final follow up


Thirty-nine of 39 non-HIV patients (22 men and 17 women; mean age, 50 years) diagnosed with ARN were enrolled in the study. Etiologies were: varicella-zoster virus in 25 eyes (64%), herpes simplex viruses in the remaining 14 eyes. The average follow-up duration was 19 ± 13 months. All patients had undergone systemic antivirals; surgery was performed in 16 eyes. The mean delay between onset of visual symptoms and antiviral treatment initiation was 15 ± 31 days (range, 1–180 days). The mean BCVA at baseline was 0.83 ± 0.75 logMAR, while the mean final BCVA was 0.75 ± 0.81 logMAR. Both initial BCVA and treatment delay (TD) were significantly correlated with the final BCVA (p < 0.05).


Initial BCVA and TD seem to be significant predictors of mid-/long-term visual outcome in non-HIV patients affected by ARN.

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  • 25 August 2020

    The original published online version contains mistake in the presentation of the first and last names of authors.


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The authors wish to thank Sally Louise Williams, MSc, and Susan Houghton for the English language editing and reviewing of the manuscript.

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Corresponding author

Correspondence to Guex-Crosier Yan.

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Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of each local Ethics Committee (i.e., Parma, Italy, ID: 1058/2018; and Lausanne, Switzerland, ID: 2019-00322) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all available individual participants included in the study.

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Paolo, M., Marta, Z., Stefania, F. et al. Visual outcome and poor prognostic factors in acute retinal necrosis syndrome. Graefes Arch Clin Exp Ophthalmol 258, 1851–1856 (2020).

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  • Acute retinal necrosis (ARN)
  • Visual outcome
  • Predictors
  • Treatment