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Choriocapillaris flow features and choroidal vasculature in the fellow eyes of patients with acute central serous chorioretinopathy

  • Retinal Disorders
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Abstract

Purpose

The purpose of the study is to investigate the characteristics of choriocapillaris flow based on the underlying choroidal vasculature in fellow eyes with central serous chorioretinopathy (CSC).

Methods

We included 57 patients with CSC and normal controls. Characteristics of choriocapillaris flow were evaluated using swept-source optical coherence tomography (OCT) angiography. We divided the choroidal layer into the vascular and stromal beds according to the choroid vessels on en-face OCT images. We compared the flow void area and mean vascular density of the choriocapillaris according to the underlying choroidal beds in the CSC and control group.

Results

The mean vascular density of the choriocapillaris in the CSC group was not different from that of the control group (P = 0.289). The flow void area was more frequently found in the CSC group (59.6%) than in the control group (29.8%, P = 0.002). The presence of the flow void area in the CSC group was associated with greater macular choroidal thickness (P = 0.004). In the CSC group, the mean flow void area and ratio of the choriocapillaris over the vascular bed were larger than those over the stromal bed (all P < 0.001).

Conclusions

The location of the flow void area of the choriocapillaris was associated with the distribution of the underlying choroidal vessels. This suggests that the underlying choroidal vessels may affect choriocapillaris perfusion in pachychoroid eyes.

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Funding

This study was funded by Korea University (grant number K1609751).

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Authors and Affiliations

  1. Department of Ophthalmology, Korea University College of Medicine, 126-1 Anam-dong 5-ga, Sungbuk-gu, Seoul, 136-705, South Korea

    Cheolmin Yun, Jungah Huh, So Min Ahn, Boram Lee, Seong-Woo Kim & Jaeryung Oh

  2. Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, South Korea

    Jee Taek Kim

  3. Department of Biostatistics, Korea University College of Medicine, Seoul, South Korea

    Soon-Young Hwang

Authors
  1. Cheolmin Yun
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Correspondence to Jaeryung Oh.

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Conflict of interest

J.O. is a consultant of Topcon Corporation. Other authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

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Yun, C., Huh, J., Ahn, S.M. et al. Choriocapillaris flow features and choroidal vasculature in the fellow eyes of patients with acute central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol 257, 57–70 (2019). https://doi.org/10.1007/s00417-018-4179-2

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