The effect of trabeculectomy on serum brain-derived neurotrophic factor levels in primary open-angle glaucoma

  • Mehmet Murat Uzel
  • Ufuk Elgin
  • Barış Boral
  • Muharrem Çiçek
  • Emine Şen
  • Burçin Şener
  • Pelin Yılmazbaş



We aimed to investigate the effect of trabeculectomy on serum brain-derived neurotrophic factor (BDNF) levels. Our secondary goal was to compare serum and aqueous humor (AH) BDNF levels in primary open-angle glaucoma (POAG) and control subjects.


This prospective, cross-sectional study consists of 20 eyes of with advanced-stage POAG who had trabeculectomy and 19 eyes of age- and sex-matched control healthy subjects who had cataract surgery. Serum and AH samples were obtained preoperatively in trabeculectomy group and control subjects. Serum samples were obtained at the third postoperative month in both groups.


The aqueous humor and serum levels of BDNF at the surgery day were found to be strongly positive correlated (r = 0.868; p < 0.001). Serum and AH BDNF levels of POAG cases were significantly lower than control subjects at the surgery day (respectively p = 0.038, p = 0.011). In POAG cases, serum BDNF levels significantly increased at the third month after trabeculectomy while there was not a significant difference in control subjects with cataract surgery (p < 0.001; p = 0.717 respectively).


Trabeculectomy was found to have a positive effect on serum BDNF levels in POAG cases.


Primary open-angle glaucoma Trabeculectomy Brain-derived neurotrophic factor 



Turkish Ophthalmology Society provided financial support for this study. The sponsor had no role in the design or conduct of this research.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (name the institution/committee) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Afyonkarahisar State HospitalAfyonkarahisarTurkey
  2. 2.University of Health Sciences, Ulucanlar Eye Research and Training HospitalAnkaraTurkey
  3. 3.Faculty of Medicine, Immunology DepartmentCukurova UniversityAdanaTurkey
  4. 4.Faculty of Medicine, Microbiology DepartmentHacettepe UniversityAnkaraTurkey

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