Advertisement

The effect of trabeculectomy on serum brain-derived neurotrophic factor levels in primary open-angle glaucoma

  • Mehmet Murat Uzel
  • Ufuk Elgin
  • Barış Boral
  • Muharrem Çiçek
  • Emine Şen
  • Burçin Şener
  • Pelin Yılmazbaş
Glaucoma

Abstract

Purpose

We aimed to investigate the effect of trabeculectomy on serum brain-derived neurotrophic factor (BDNF) levels. Our secondary goal was to compare serum and aqueous humor (AH) BDNF levels in primary open-angle glaucoma (POAG) and control subjects.

Methods

This prospective, cross-sectional study consists of 20 eyes of with advanced-stage POAG who had trabeculectomy and 19 eyes of age- and sex-matched control healthy subjects who had cataract surgery. Serum and AH samples were obtained preoperatively in trabeculectomy group and control subjects. Serum samples were obtained at the third postoperative month in both groups.

Results

The aqueous humor and serum levels of BDNF at the surgery day were found to be strongly positive correlated (r = 0.868; p < 0.001). Serum and AH BDNF levels of POAG cases were significantly lower than control subjects at the surgery day (respectively p = 0.038, p = 0.011). In POAG cases, serum BDNF levels significantly increased at the third month after trabeculectomy while there was not a significant difference in control subjects with cataract surgery (p < 0.001; p = 0.717 respectively).

Conclusion

Trabeculectomy was found to have a positive effect on serum BDNF levels in POAG cases.

Keywords

Primary open-angle glaucoma Trabeculectomy Brain-derived neurotrophic factor 

Notes

Funding

Turkish Ophthalmology Society provided financial support for this study. The sponsor had no role in the design or conduct of this research.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (name the institution/committee) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    Chang EE, Goldberg (2012) JLGlaucoma 2.0: neuroprotection, neuroregeneration, neuroenhancement. Ophthalmology 119:979–986Google Scholar
  2. 2.
    Miglior S, Bertuzzi F (2013) Relationship between intraocular pressure and glaucoma onset and progression. Curr Opin Pharmacol 13:32–35CrossRefPubMedGoogle Scholar
  3. 3.
    Smith MA, Xia CZ, Dengler-Crish CM, Fening KM, Inman DM, Schofield BR, Crish SD (2016) Persistence of intact retinal ganglion cell terminals after axonal transport loss in the DBA/2J mouse model of glaucoma. J Comp Neurol 1(524):3503–3517CrossRefGoogle Scholar
  4. 4.
    Fahy ET, Chrysostomou V, Abbott CJ, van Wijngaarden P, Crowston JG (2016) Axonal transport along retinal ganglion cells is grossly intact during reduced function post-injury. Exp Eye Res 146:289–292CrossRefPubMedGoogle Scholar
  5. 5.
    Johnson TV, Bull ND, Martin KR (2011) Neurotrophic factor delivery as a protective treatment for glaucoma. Exp Eye Res 93:196–203CrossRefPubMedGoogle Scholar
  6. 6.
    Feng L, Chen H, Yi J, Troy JB, Zhang HF, Liu X (2016) Long-term protection of retinal ganglion cells and visual function by brain-derived neurotrophic factor in mice with ocular hypertension. Invest Ophthalmol Vis Sci 57:3793–3802CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Ghaffariyeh A, Honarpisheh N, Heidari MH, Puyan S, Abasov F (2011) Brain-derived neurotrophic factor as a biomarker in primary open-angle glaucoma. Optom Vis Sci 88:80–85CrossRefPubMedGoogle Scholar
  8. 8.
    Schehlein EM, Novack GD, Robin AL (2017) New classes of glaucoma medications. Curr Opin Ophthalmol 28:161–168PubMedGoogle Scholar
  9. 9.
    Vinod K, Gedde SJ (2017) Clinical investigation of new glaucoma procedures. Curr Opin Ophthalmol 28:187–193PubMedGoogle Scholar
  10. 10.
    Sawchyn AK, Slabaugh MA (2016) Innovations and adaptations in trabeculectomy. Curr Opin Ophthalmol 27:158–163CrossRefPubMedGoogle Scholar
  11. 11.
    Wittström E, Schatz P, Lövestam-Adrian M, Ponjavic V, Bergström A, Andréasson S (2010) Improved retinal function after trabeculectomy in glaucoma patients. Graefes Arch Clin Exp Ophthalmol 248:485–495CrossRefPubMedGoogle Scholar
  12. 12.
    Magacho L, Henderer JD, Lankaranian D, Steinmann WC, Spaeth GL (2006) Improvement in colour vision parameters following successful trabeculectomy. Acta Ophthalmol Scand 84:201–205CrossRefPubMedGoogle Scholar
  13. 13.
    Caprioli J, de Leon JM, Azarbod P, Chen A, Morales E, Nouri-Mahdavi K, Coleman A, Yu F, Afifi A (2016) Trabeculectomy can improve long-term visual function in glaucoma. Ophthalmology 123:117–128CrossRefPubMedGoogle Scholar
  14. 14.
    Quigley HA, McKinnon SJ, Zack DJ, Pease ME, Kerrigan-Baumrind LA, Kerrigan DF, Mitchell RS (2000) Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats. Invest Ophthalmol Vis Sci 41:3460–3466PubMedGoogle Scholar
  15. 15.
    Pease ME, McKinnon SJ, Quigley HA, Kerrigan-Baumrind LA, Zack DJ (2000) Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma. Invest Ophthalmol Vis Sci 41:764–774PubMedGoogle Scholar
  16. 16.
    The Advanced Glaucoma Intervention Study Investigators (1994) Advanced Glaucoma Intervention Study. 2. Visual field test scoring and reliability. Ophthalmology 101(8):1445–1455CrossRefGoogle Scholar
  17. 17.
    Takihara Y, Inatani M, Fukushima M, Iwao K, Iwao M, Tanihara H (2009) Trabeculectomy with mitomycin C for neovascular glaucoma: prognostic factors for surgical failure. Am J Ophthalmol 147:912–918CrossRefPubMedGoogle Scholar
  18. 18.
    Harper MM, Grozdanic SD, Blits B, Kuehn MH, Zamzow D, Buss JE, Kardon RH, Sakaguchi DS (2011) Transplantation of BDNF-secreting mesenchymal stem cells provides neuroprotection in chronically hypertensive rat eyes. Invest Ophthalmol Vis Sci 23(52):4506–4515CrossRefGoogle Scholar
  19. 19.
    Oddone F, Roberti G, Micera A, Busanello A, Bonini S, Quaranta L, Agnifili L, Manni G (2017) Exploring serum levels of brain derived neurotrophic factor and nerve growth factor across glaucoma stages. PLoS One. 9 12(1):e0168565CrossRefGoogle Scholar
  20. 20.
    Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ (1998) Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 37:1553–1561CrossRefPubMedGoogle Scholar
  21. 21.
    Herzog KH, von Bartheld CS (1998) Contributions of the optic tectum and the retina as sources of brain-derived neurotrophic factor for retinal ganglion cells in the chick embryo. J Neurosci 18:2891–2906CrossRefPubMedGoogle Scholar
  22. 22.
    Ghaffariyeh A, Honarpisheh N, Shakiba Y, Puyan S, Chamacham T, Zahedi F, Zarrineghbal M (2009) Brain-derived neurotrophic factor in patients with normal-tension glaucoma. Optometry 80:635–638CrossRefPubMedGoogle Scholar
  23. 23.
    Lommatzsch M, Zingler D, Schuhbaeck K, Schloetcke K, Zingler C, Schuff-Werner P, Virchow JC (2005) The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol Aging 26:115–123CrossRefPubMedGoogle Scholar
  24. 24.
    Laske C, Stransky E, Leyhe T, Eschweiler GW, Maetzler W, Wittorf A, Soekadar S, Richartz Z, Koehler N, Bartels M, Buchkremer G, Schott K (2007) BDNF serum and CSF concentrations in Alzheimer’s disease, normal pressure hydrocephalus and healthy controls. J Psychiatr Res 41:387–394CrossRefPubMedGoogle Scholar
  25. 25.
    Azoulay D, Urshansky N, Karni A (2008) Low and dysregulated BDNF secretion from immune cells of MS patients is related to reduced neuroprotection. J Neuroimmunol 195:186–193CrossRefPubMedGoogle Scholar
  26. 26.
    Goldshtein I, Shalev V, Zigman N, Chodick G, Levkovitch-Verbin H (2016) The Maccabi Glaucoma Study: treatment patterns and persistence with glaucoma therapy in a large Israeli health maintenance organization. J Glaucoma 25(4):e386–e391CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Afyonkarahisar State HospitalAfyonkarahisarTurkey
  2. 2.University of Health Sciences, Ulucanlar Eye Research and Training HospitalAnkaraTurkey
  3. 3.Faculty of Medicine, Immunology DepartmentCukurova UniversityAdanaTurkey
  4. 4.Faculty of Medicine, Microbiology DepartmentHacettepe UniversityAnkaraTurkey

Personalised recommendations