Dear Sirs,

New York City (NYC) was the first epicenter of the coronavirus disease 2019 (COVID-19) pandemic in the United States. Beginning in mid-March 2020, the number of deaths in NYC increased above the typical ~ 1000/week, eventually reaching 7726 deaths in the week ending April 11 [1]. That same week, 4441 NYC deaths were attributed to COVID-19 [1]. This suggests there were 3285 non-COVID deaths that week, over 2000 of which were excess. These excess non-COVID deaths were attributed to 11 categories, including the main neurological causes of death—cerebrovascular and Alzheimer’s disease [2]. We compared the excess non-COVID deaths from cerebrovascular and Alzheimer’s disease to other causes of death.

This is a secondary analysis of the National Center for Health Statistics Provisional Death Counts [1]. The cause of death is adjudicated from death certificates using NCHS methodology, but may be later updated to reflect new data [3]. The primary outcome is the excess non-COVID deaths of the eleven NCHS-specified natural causes of death, including cardiac, malignancy, renal, diabetes, influenza/pneumonia, chronic lower respiratory disease, other respiratory, sepsis, other/undetermined, Alzheimer’s disease, and cerebrovascular in NYC for the weeks ending 01/04/20–06/20/20. Eighteen data points were missing, in which case we carried forward the prior value. Because the first excess non-COVID deaths were recorded in the week ending 03/21/20, we stratified by 11-week periods ending 01/04/20–03/14/20 and 03/21/20–05/30/20, to calculate percentage change and test for differences using Student’s t test.

For 01/04/20–03/14/20, the average weekly number of natural deaths in NYC was 1101 (range 1049–1142), while for 03/21/20–05/30/20, the average was 3247 (range 1128–7682), a 195% increase (p < 0.001) (Fig. 1a). Figure 1a shows excess deaths return to a near normal level after 05/30/20. During 03/21/20–05/30/20, COVID-19 deaths averaged 1578 a week, failing to account for the entirety of excess death. Figure 1b shows the concept of excess non-COVID deaths, which averaged 1670/week during 03/21/20–05/30/20.

Fig. 1
figure 1

Weekly natural deaths in NYC between the weeks ending 01/04/20 and 06/20/20. a All natural deaths, with COVID-19 deaths shown in light blue. b Illustration of the excess death (orange) attributed to non-COVID causes. c The weekly counts of deaths from the 11 non-COVID causes. d Interactive figure of the weekly death counts: https://www.icloud.com/pages/0vW0yM-3-PwN8m3IAR6F5DTHQ#Figure_1D. e Percentage change in the non-COVID causes of death, comparing the weeks ending 03/21/20–05/30/20 to the weeks ending 01/04/20–03/14/20

The causes of non-COVID excess death are shown in Fig. 1c, illustrating a prominent increase in cardiac death, which was the most common non-COVID excess cause of death. An interactive figure of all the COVID-19 and non-COVID excess deaths is at https://www.icloud.com/pages/0vW0yM-3-PwN8m3IAR6F5DTHQ#Figure_1D. The percentage changes are in Fig. 1e. Deaths attributed to cerebrovascular and Alzheimer’s disease increased 11.8% and 38.9%, respectively, from an average of 41.2 to 49.0 a week for cerebrovascular (p = 0.194) and 21.3 to 29.6 a week for Alzheimer’s (p = 0.126).

In mid-March 2020, after the rise in COVID-19 infections in NYC, excess non-COVID deaths increased for cerebrovascular and Alzheimer’s disease, but this increase was far less than multiple other causes of death. Lack of widespread COVID-19 testing during this period [4] means that many of the excess non-COVID deaths were likely due to complications from undiagnosed COVID-19. While neurologic complications have been reported with COVID-19 infection, they are not as common as other organ systems [5, 6]. The relatively small 11.8% increase in cerebrovascular death suggests that while stroke may complicate COVID-19 infection, it may not be as fatal as other complications. The larger 38.9% increase in Alzheimer’s deaths may reflect their goals of care or older age [5, 6]. The other possible explanation for the excess non-COVID deaths is that there was reduced access to healthcare during the pandemic in NYC.

The main limitation of our study is that NCHS cause of death may not reliably identify the underlying cause of death, particularly in the absence of widespread COVID-19 testing. These data are also provisional and are subject to revision. Despite these limitations, we found that the two most common neurological causes of death, cerebrovascular and Alzheimer’s disease, increased comparatively less than pulmonary, cardiac, and diabetic deaths in NYC during the recent peak of COVID-19 mortality.