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Alternating monocular adducting saccadic pulses and dissociated adducting nystagmus during lateral gazes in spinocerebellar ataxia type 3 | SpringerLink

Alternating monocular adducting saccadic pulses and dissociated adducting nystagmus during lateral gazes in spinocerebellar ataxia type 3

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Fig. 1

References

  1. 1.

    Kawaguchi Y, Okamoto T, Taniwaki M, Aizawa M, Inoue M, Katayama S, Kawakami H, Nakamura S, Nishimura M, Akiguchi I (1994) CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32. 1. Nat Genet 8(3):221

    CAS  Article  Google Scholar 

  2. 2.

    Leigh RJ, Zee DS (2015) The neurology of eye movements. Oxford University Press, New York

    Google Scholar 

  3. 3.

    Otero-Millan J, Serra A, Leigh RJ, Troncoso XG, Macknik SL, Martinez-Conde S (2011) Distinctive features of saccadic intrusions and microsaccades in progressive supranuclear palsy. J Neurosci 31(12):4379–4387

    CAS  Article  Google Scholar 

  4. 4.

    Oh EH, Choi S-Y, Choi K-D, Choi J-H (2019) Monocular single saccadic pulses. J Neuroopthalmol 39(2):237–239

    Article  Google Scholar 

  5. 5.

    Herishanu YO, Sharpe JA (1983) Saccadic intrusions in internuclear ophthalmoplegia. Ann Neurol 14(1):67–72

    CAS  Article  Google Scholar 

  6. 6.

    Lee ES, Choi JY, Kim JS (2017) Teaching video neuroimages: alternating horizontal single saccadic pulses in progressive supranuclear palsy. Neurology 88(3):e32–e33

    Article  Google Scholar 

  7. 7.

    Lemos J, Novo A, Duque C, Castelhano J, Eggenberger E, Januário C (2018) “Pinball” intrusions in spinocerebellar ataxia type 3. Neurology 90(1):36–37

    Article  Google Scholar 

  8. 8.

    Bahill AT, Troost BT (1979) Types of saccadic eye movements. Neurology 29(8):1150–1152

    CAS  Article  Google Scholar 

  9. 9.

    Clendaniel RA, Mays LE (1994) Characteristics of antidromically identified oculomotor internuclear neurons during vergence and versional eye movements. J Neurophysiol 71(3):1111–1127

    CAS  Article  Google Scholar 

  10. 10.

    Christova P, Anderson JH, Gomez CM (2008) Impaired eye movements in presymptomatic spinocerebellar ataxia type 6. Arch Neurol 65(4):530–536

    Article  Google Scholar 

  11. 11.

    Jacobi H, Reetz K, du Montcel ST, Bauer P, Mariotti C, Nanetti L, Rakowicz M, Sulek A, Durr A, Charles P (2013) Biological and clinical characteristics of individuals at risk for spinocerebellar ataxia types 1, 2, 3, and 6 in the longitudinal RISCA study: analysis of baseline data. Lancet Neurol 12(7):650–658

    Article  Google Scholar 

Download references

Funding

This study was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (No. NRF-2016R1D1A1B04935568).

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Affiliations

Authors

Contributions

Dr. Lee analyzed and interpreted the data and wrote the manuscript. Drs. H.J. Kim, and Choi analyzed and interpreted the data, and revised the manuscript. Drs. J.S. Kim designed and conceptualized the study, interpreted the data, and revised the manuscript.

Corresponding author

Correspondence to Ji-Soo Kim.

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Conflicts of interest

Drs. S.U. Lee, H.J. Kim, and J.Y. Choi report no disclosures. Dr. J.S. Kim serves as an associate editor of Frontiers in Neuro-otology and on the editorial boards of the Journal of Clinical Neurology, Frontiers in Neuro-ophthalmology, Journal of Neuro-ophthalmology, Journal of Vestibular Research, Journal of Neurology, and Medicine.

Ethical approval

This study followed the tenets of the Declaration of Helsinki and was performed according to the guidelines of Institutional Review Board of Seoul National University Bundang Hospital (B-1906-549-701).

Electronic supplementary material

Below is the link to the electronic supplementary material.

Video 1 Exotropia is evident during alternating cover test (MP4 21470 kb)

Video 2 The patient shows alternating monocular adducting saccades in both eyes followed by glissadic eye movements (MP4 1768 kb)

Video 3 The patient shows a pulse-step mismatch, especially in the adducting eye, and dissociated adducting nystagmus during horizontal saccades. Vertical saccades are slow in both directions and show a pulse-step mismatch upward (MP4 42619 kb)

Supplementary material 1 (DOCX 34 kb)

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Lee, SU., Kim, HJ., Choi, JY. et al. Alternating monocular adducting saccadic pulses and dissociated adducting nystagmus during lateral gazes in spinocerebellar ataxia type 3. J Neurol 267, 279–281 (2020). https://doi.org/10.1007/s00415-019-09609-1

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