References
Cohen JA, Coles AJ, Arnold DL, Confavreux C, Fox EJ, Hartung HP, Havrdova E, Selmaj KW, Weiner HL, Fisher E, Brinar VV, Giovannoni G, Stojanovic M, Ertik BI, Lake SL, Margolin DH, Panzara MA, Compston DA (2012) Investigators C-MI. Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomized controlled phase 3 trial. Lancet 380:1819–1828
Coles AJ, Twyman CL, Arnold DL, Cohen JA, Confavreux C, Fox EJ, Hartung HP, Havrdova E, Selmaj KW, Weiner HL, Miller T, Fisher E, Sandbrink R, Lake SL, Margolin DH, Oyuela P, Panzara MA, Compston DA (2012) Investigators C-MI. Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial. Lancet 380:1829–1839
Havrdova E, Horakova D, Kovarova I (2015) Alemtuzumab in the treatment of multiple sclerosis: key clinical trial results and considerations for use. Ther Adv Neurol Disord 8:31–45
Coles AJ, Cohen JA, Fox EJ, Giovannoni G, Hartung HP, Havrdova E, Schippling S, Selmaj KW, Traboulsee A, Compston DAS, Margolin DH, Thangavelu K, Chirieac MC, Jody D, Xenopoulos P, Hogan RJ, Panzara MA, Arnold DL (2017) Alemtuzumab CARE-MS II 5-year follow-up: Efficacy and safety findings. Neurology 89:1117–1126
Malmeström C, Andersson BA, Lycke J (2014) First reported case of diabetes mellitus type 1 as a possible secondary autoimmune disease following alemtuzumab treatment in MS. J Neurol 261:2016–2018
Wertman E, Zilber N, Abramsky O (1992) An association between multiple sclerosis and type I diabetes mellitus. J Neurol 239:43–45
Marrosu MG, Cocco E, Lai M, Spinicci G, Pischedda MP, Contu P (2002) Patients with multiple sclerosis and risk of type 1 diabetes mellitus in Sardinia, Italy: a cohort study. Lancet 359:1461–1465
Hussein WI, Reddy SS (2006) Prevalence of diabetes in patients with multiple sclerosis. Diabetes Care 29:1984–1985
Ruck T, Pfeuffer S, Schulte-Mecklenbeck A, Gross CC, Lindner M, Metze D, Ehrchen J, Sondermann W, Pul R, Kleinschnitz C, Wiendl H, Meuth MD, Klotz SG (2018) L. Vitiligo after alemtuzumab treatment, Secondary autoimmunity is not all about B cells. Neurology 91:e2233–e2237
Della Valle P, Coluccia A, Martinelli V, Comi G, D´Angelo A, Moiola L (2018) Acquired haemophilia a as a secondary autoimmune disease after alemtuzumab treatment in multiple sclerosis: a case report. Mult Scler Relat Disord 27:403–405
Hoffman BM, Zeid NA, Alam U, Caress JB (2019) Lambert-Eaton myasthenic syndrome associated with alemtuzumab administration. Mult Scler Relat Disord 27:131–132
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Stephan Richter has received honoraria for advisory board councils and travel expenses for attending meetings from Biogen, Celgene, Genzyme, Merck, Novartis and Roche. Bert Wagner has received honoraria for advisory board councils and travel expenses for attending meetings from Biogen, Genzyme, Merck, Novartis and Roche. Elisabeth G. Celius has received honoraria for advisory boards and/or speaker honoraria from Biogen, Merck, Roche, Novartis, Genzyme and Teva, and unrestricted research grants from Novartis and Genzyme.
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Richter, S., Wagner, B. & Celius, E.G. Two cases of diabetes mellitus type 1 after alemtuzumab treatment for multiple sclerosis: another probable secondary autoimmune disease. J Neurol 266, 1270–1271 (2019). https://doi.org/10.1007/s00415-019-09257-5
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DOI: https://doi.org/10.1007/s00415-019-09257-5