Abstract
Background
Cervicocerebral artery dissection (CAD) is a major cause of ischemic stroke in young adults. There are many existing studies on determinants for CAD; however, they are still not totally defined. We conduct the study to further investigate the determinants for CAD based on ischemic stroke patients.
Methods
81 ischemic stroke patients with CAD were enrolled in the CAD stroke group and 84 ischemic stroke patients without CAD were enrolled in the non-CAD stroke group. Their clinical data, such as age, gender, vascular risk factors, headache and neck pain and clinical laboratory data, were collected to analyze the differences between the two groups.
Results
A total of 165 ischemic stroke patients were included. The mean age of CAD stroke group was (51.6 ± 12.4) years, and (55.5 ± 8.1) years in non-CAD stroke group, with a statistically significant difference (P = 0.017). The average level of triglycerides in CAD stroke group was (1.3 ± 0.7) mmol/L, and (1.7 ± 1.1) mmol/L in non-CAD stroke group, with a statistically significant difference (P = 0.012). There were 42.0% (34/81) of headache and neck pain in CAD stroke group and 22.6% (19/84) in non-CAD stroke group, with a statistically significant difference (P = 0.008). The key findings with significant difference were stratified and multivariate logistic regression analysis showed that age < 50 years old (OR 2.98, 95% CI 1.43–6.21, P = 0.004), triglycerides < 1.6 mmol/L (OR 3.51, 95% CI 1.69–7.27, P = 0.001) and headache and neck pain (OR 2.94, 95% CI 1.39–6.20, P = 0.005) showed a positive correlation with CAD.
Conclusion
In the process of diagnosis and treatment of ischemic stroke, for patients with age < 50 years old, headache and neck pain and triglycerides < 1.6 mmol/L, the cervicocerebral artery dissection should be considered, and vascular imaging examination needs to be performed in time.
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Acknowledgements
The authors thank the patients for their collaboration.
Funding
This study was supported by the Grant from National Natural Science Foundation of China (no. 81771397); The National Natural Science Foundation of China, Youth Science Foundation Project (no. 81701271).
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The authors declare no conflict of interest.
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All subjects gave their informed consent prior to their inclusion in the study. The Ethics Committee of the First Affiliated Hospital of Zhengzhou University approved this study (Number: KW-2018-LW-006).
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Cheng, W., Wang, Y., Lian, Y. et al. A case–control study of the determinants for cervicocerebral artery dissection. J Neurol 266, 119–123 (2019). https://doi.org/10.1007/s00415-018-9096-0
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DOI: https://doi.org/10.1007/s00415-018-9096-0