Skip to main content

Advertisement

SpringerLink
Log in

MicroRNA profile of human endo-/perilymph

  • Letter to the Editors
  • Published:
Journal of Neurology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Davies DG (1968) Biochemistry of the inner ear fluids—experimental and clinical observations. J Laryngol Otol 82(4):301–311

    Article  CAS  Google Scholar 

  2. Ghanem TA, Breneman KD, Rabbitt RD, Brown HM (2008) Ionic composition of endolymph and perilymph in the inner ear of the oyster toadfish, Opsanus tau. Biol Bull 214(1):83–90

    Article  CAS  Google Scholar 

  3. Stover T, Diensthuber M (2011) Molecular biology of hearing. GMS Curr Top Otorhinolaryngol Head Neck Surg 10:Doc06. https://doi.org/10.3205/cto000079

    Article  PubMed  Google Scholar 

  4. Lysaght AC, Kao SY, Paulo JA, Merchant SN, Steen H, Stankovic KM (2011) Proteome of human perilymph. J Proteome Res 10(9):3845–3851. https://doi.org/10.1021/pr200346q

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Swan EE, Peppi M, Chen Z, Green KM, Evans JE, McKenna MJ, Mescher MJ, Kujawa SG, Sewell WF (2009) Proteomics analysis of perilymph and cerebrospinal fluid in mouse. Laryngosc 119(5):953–958. https://doi.org/10.1002/lary.20209

    Article  CAS  Google Scholar 

  6. Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116(2):281–297

    Article  CAS  Google Scholar 

  7. Sorensen SS, Nygaard AB, Nielsen MY, Jensen K, Christensen T (2014) miRNA expression profiles in cerebrospinal fluid and blood of patients with acute ischemic stroke. Transl Stroke Res 5(6):711–718. https://doi.org/10.1007/s12975-014-0364-8

    Article  CAS  PubMed  Google Scholar 

  8. Teplyuk NM, Mollenhauer B, Gabriely G, Giese A, Kim E, Smolsky M, Kim RY, Saria MG, Pastorino S, Kesari S, Krichevsky AM (2012) MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity. Neuro Oncol 14(6):689–700. https://doi.org/10.1093/neuonc/nos074

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K, Guo J, Zhang Y, Chen J, Guo X, Li Q, Li X, Wang W, Zhang Y, Wang J, Jiang X, Xiang Y, Xu C, Zheng P, Zhang J, Li R, Zhang H, Shang X, Gong T, Ning G, Wang J, Zen K, Zhang J, Zhang CY (2008) Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 18(10):997–1006. https://doi.org/10.1038/cr.2008.282

    Article  CAS  PubMed  Google Scholar 

  10. Gantier MP, McCoy CE, Rusinova I, Saulep D, Wang D, Xu D, Irving AT, Behlke MA, Hertzog PJ, Mackay F, Williams BR (2011) Analysis of microRNA turnover in mammalian cells following Dicer1 ablation. Nucleic Acids Res 39(13):5692–5703. https://doi.org/10.1093/nar/gkr148

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Nagy C, Maheu M, Lopez JP, Vaillancourt K, Cruceanu C, Gross JA, Arnovitz M, Mechawar N, Turecki G (2015) Effects of postmortem interval on biomolecule integrity in the brain. J Neuropathol Exp Neurol 74(5):459–469. https://doi.org/10.1097/NEN.0000000000000190

    Article  PubMed  Google Scholar 

  12. Lu C, Shan Z, Hong J, Yang L (2017) MicroRNA-92a promotes epithelial-mesenchymal transition through activation of PTEN/PI3K/AKT signaling pathway in non-small cell lung cancer metastasis. Int J Oncol 51(1):235–244. https://doi.org/10.3892/ijo.2017.3999

    Article  CAS  PubMed  Google Scholar 

  13. Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D, Slack FJ (2005) RAS is regulated by the let-7 microRNA family. Cell 120(5):635–647. https://doi.org/10.1016/j.cell.2005.01.014

    Article  CAS  PubMed  Google Scholar 

  14. Lv G, Wu M, Wang M, Jiang X, Du J, Zhang K, Li D, Ma N, Peng Y, Wang L, Zhou L, Zhao W, Jiao Y, Gao X, Hu Z (2017) miR-320a regulates high mobility group box 1 expression and inhibits invasion and metastasis in hepatocellular carcinoma. Liver Int 37(9):1354–1364. https://doi.org/10.1111/liv.13424

    Article  CAS  PubMed  Google Scholar 

  15. Buckingham RA, Valvassori GE (2001) Inner ear fluid volumes and the resolving power of magnetic resonance imaging: can it differentiate endolymphatic structures? Ann Otol Rhinol Laryngol 110(2):113–117. https://doi.org/10.1177/000348940111000204

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

Funded by the German Federal Ministry of Education and Research (German Center for Vertigo and Balance Disorders, Grant code 01EO1401). We thank Katie Göttlinger for copyediting the manuscript.

Author information

Authors and Affiliations

  1. Department of Neurology, German Center for Vertigo and Balance Disorders, DSGZ, Klinikum Grosshadern, Ludwig Maximilians University, Feodor-Lynen-Str. 19, 81377, Munich, Germany

    Markus Rohde, Michael Strupp & Susanne Himmelein

  2. German Center for Vertigo and Balance Disorders, DSGZ, Ludwig Maximilians University, Munich, Germany

    Markus Rohde, Anja Horn, Michael Strupp & Susanne Himmelein

  3. Department of Legal Medicine, Ludwig Maximilians University, Munich, Germany

    Inga Sinicina

  4. Institute of Anatomy and Cell Biology I, Ludwig Maximilians University, Munich, Germany

    Anja Horn

  5. Laboratory for RNA Biology, Biochemistry Center Regensburg (BZR), Regensburg, Germany

    Norbert Eichner & Gunter Meister

Authors
  1. Markus Rohde
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Inga Sinicina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anja Horn
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Norbert Eichner
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Gunter Meister
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Michael Strupp
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Susanne Himmelein
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Susanne Himmelein.

Ethics declarations

Conflicts of interest

The authors declare that they have no conflict of interest.

Ethical standard statement

The study was approved by the Ethical Committee of the Medical Faculty of the Ludwig Maximilians University of Munich. For blood samples signed written consent was obtained from all participants. No written consent was given for endo-/perilymph as they were obtained post-mortem.

Additional information

This manuscript is part of a supplement sponsored by the German Federal Ministry of Education and Research within the funding initiative for integrated research and treatment centers.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rohde, M., Sinicina, I., Horn, A. et al. MicroRNA profile of human endo-/perilymph. J Neurol 265 (Suppl 1), 26–28 (2018). https://doi.org/10.1007/s00415-018-8862-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-018-8862-3

Search

Navigation