Adult-onset Alexander disease with an R66Q mutation in GFAP presented with severe vocal cord paralysis during sleep

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Acknowledgments

We thank Crimson Interactive Pvt. Ltd. for English editing and proofreading.

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Correspondence to Ayumi Hida.

Electronic supplementary material

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Awake-laryngofiberscopy showed mild abduction restriction during inspiration and glottic stenosis during expiration. (MP4 3717 kb)

After intravenous diazepam (5 mg) administration, the bilateral vocal cords were almost fixed in the paramedian position, and only a 1-mm hole remained during inspiration. (MP4 4344 kb)

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Hida, A., Ishiura, H., Arai, N. et al. Adult-onset Alexander disease with an R66Q mutation in GFAP presented with severe vocal cord paralysis during sleep. J Neurol 259, 2234–2236 (2012). https://doi.org/10.1007/s00415-012-6540-4

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Keywords

  • Obstructive Sleep Apnea
  • Glial Fibrillary Acidic Protein
  • Vocal Cord
  • Obstructive Sleep Apnea Syndrome
  • Multiple System Atrophy