Levodopa-induced breathing, cognitive and behavioral changes in Parkinson’s disease

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Fig. 1

References

  1. 1.

    Pal PK, Sathyaprabha TN, Tuhina P, Thennarasu K (2007) Pattern of subclinical pulmonary dysfunctions in Parkinson’s disease and the effect of levodopa. Mov Disord 22(3):420–424

    PubMed  Article  Google Scholar 

  2. 2.

    Mehanna R, Jankovic J (2010) Respiratory problems in neurologic movement disorders. Parkinsonism Relat Disord 16:628–638

    PubMed  Article  Google Scholar 

  3. 3.

    Rice JE, Antic R, Thompson PD (2002) Disordered respiration as a levodopa-induced dyskinesia in Parkinson’s disease. Mov Disord 17(3):524–527

    PubMed  Article  CAS  Google Scholar 

  4. 4.

    Jankovic J, Nour F (1986) Respiratory dyskinesia in Parkinson’s disease. Neurology 36:303–304

    PubMed  CAS  Google Scholar 

  5. 5.

    De Keyser J, Vincken W (1985) L-dopa-induced respiratory disturbance in Parkinson’s disease suppressed by tiapride. Neurology 35(2):235–237

    PubMed  Google Scholar 

  6. 6.

    Weiner WJ, Goetz CG, Nausieda PA, Klawans HL (1978) Respiratory dyskinesias: extrapyramidal dysfunction and dyspnea. Ann Intern Med 88(3):327–331

    PubMed  CAS  Google Scholar 

  7. 7.

    Farid K, Sibon I, Guehl D, Cuny E, Burbaud P, Allard M (2009) Brain dopaminergic modulation associated with executive function in Parkinson’s disease. Mov Disord 24(13):1962–1969

    PubMed  Article  Google Scholar 

  8. 8.

    Cools R, Barker RA, Sahakian BJ, Robbins TW (2001) Enhanced or impaired cognitive function in Parkinson’s disease as a function of dopaminergic medication and task demands. Cereb Cortex 11:1136–1143

    PubMed  Article  CAS  Google Scholar 

Download references

Acknowledgments

We thank the patient for providing written consent for publication of his case history and videos. We also thank Francesca Arcuri (Neurofisiopatologia, Azienda Ospedaliera di Perugia, Italy) for technical support.

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Correspondence to Nicola Tambasco.

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Segment 1. In this segment, in baseline condition, the patient is quiet, well-oriented and cooperative (MPG 2,656 kb).

Segment 2. In this segment, 50 min after l-dopa challenge, the patient becomes dyspnoic (MPG 1,868 kb).

Segment 3. Ten minutes thereafter, the patient is anxious, uncooperative and confused with irregular breathing (MPG 4,006 kb)

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Tambasco, N., Belcastro, V., Gallina, A. et al. Levodopa-induced breathing, cognitive and behavioral changes in Parkinson’s disease. J Neurol 258, 2296–2299 (2011). https://doi.org/10.1007/s00415-011-6119-5

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Keywords

  • Levodopa
  • Tiapride
  • Irregular Breathing
  • Levodopa Intake
  • Denervation Hypersensitivity