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In vivo voxel-based relaxometry in amyotrophic lateral sclerosis

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Abstract

We applied voxel-based relaxometry (VBR) in 12 ALS patients and 12 matched healthy controls and compared the results with those of voxel-based morphometry (VBM). VBR revealed a reduced relaxation rate in the right precentral gyrus and ventral pons. Individual region of interest (ROI)-based analysis of R2 maps confirmed our VBR results. VBM depicted a reduction of white matter in the paracentral lobules and in the right middle cerebellar peduncle. Our data suggests that VBR and ROI analysis of R2 maps may have a higher sensitivity in detecting local tissue atrophy in the motor cortex and along the corticospinal tract than VBM. Larger prospective studies are necessary to evaluate the usefulness and relevance of VBR and ROI-based analysis of R2 maps in clinical practice.

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Authors and Affiliations

  1. Dept. of Neurology, University Hospital of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany

    Martina Minnerop MD, Christoph Grothe MD, Ullrich Wüllner MD & Thomas Klockgether MD

  2. Brain Imaging Center West (BICW), Leo-Brandt-Str. 1, 52425, Jülich, Germany

    Martina Minnerop MD

  3. Dept. of Biological and Medical Psychology, University of Bergen & Department of Medical Engineering, Haukeland University Hospital, Jonas lies vei 91, 5009, Bergen, Norway

    Karsten Specht PhD

  4. Medical Center Bonn, Spessartstr. 9, 53119, Bonn, Germany

    Jürgen Ruhlmann MD

Authors
  1. Martina Minnerop MD
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  2. Karsten Specht PhD
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  3. Jürgen Ruhlmann MD
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  4. Christoph Grothe MD
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  5. Ullrich Wüllner MD
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  6. Thomas Klockgether MD
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Correspondence to Martina Minnerop MD.

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Minnerop, M., Specht, K., Ruhlmann, J. et al. In vivo voxel-based relaxometry in amyotrophic lateral sclerosis. J Neurol 256, 28–34 (2009). https://doi.org/10.1007/s00415-009-0947-6

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  • DOI: https://doi.org/10.1007/s00415-009-0947-6

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