References
Gowan GM, Herrington JD, Simonetta AB (2002) Methotrexate-induced toxic leukoencephalopathy. Pharmacotherapy 9:1183–1187
Mahoney DH Jr, Shuster JJ, Nitschke R, Lauer SJ, Steuber CP, Winick N, Camitta B (1998) Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: an association with intermediate-dose intravenous methotrexate and intrathecal triple therapy—a Pediatric Oncology Group study. J Clin Oncol 5:1712–1722
Hinchey J, Chaves C, Appignani B, Breen J, Pao L, Wang A, Pessin MS, Lamy C, Mas JL, Caplan LR (1996) A reversible posterior leukoencephalopathy syndrome. N Engl J Med 334:494–500
Sanchez-Carpintero R, Narbona J, Lopez de Mesa R, Arbizu J, Sierrasesumaga L (2001) Transient posterior encephalopathy induced by chemotherapy in children. Pediatr Neurol 2:145–148
Bates SE, Raphaelson MI, Price RA, McKeever P, Cohen S, Poplack DG (1985) Ascending myelopathy after chemotherapy for central nervous system acute lymphoblastic leukemia: correlation with cerebrospinal fluid myelin basic protein. Med Pediatr Oncol 13:4–8
Ozon A, Topaloglu H, Cila A, Gunay M, Cetin M (1994) Acute ascending myelitis and encephalopathy after intrathecal cytosine arabinoside and methotrexate in an adolescent boy with acute lymphoblastic leukemia. Brain Dev 3:246–248
Vezmar S, Becker A, Bode U, Jaehde U (2003) Biochemical and clinical aspects of methotrexate neurotoxicity. Chemotherapy 49(1–2):92–104
Sandoval C, Kutscher M, Jayabose S, Tenner M (2003) Neurotoxicity of intrathecal methotrexate: MR imaging findings. AJNR Am J Neuroradiol 9:1887–1890
Karabacak NI, Ozturk G, Gucuyener K, Gokcora N, Gursel T (1997) Assessment of brain perfusion by 99mTc-HMPAO SPECT in akinetic mutism due to high-dose intravenous methotrexate therapy. Childs Nerv Syst 13:562–562
Cohen IJ, Stark B, Kaplinsky C, Weitz R, Matz S, Lerman P, Rakowsky E, Vogel R, Zaizov R (1990) Methotrexate-induced leukoencephalopathy is treatable with high-dose folinic acid: a case report and analysis of the literature. Pediatr Hematol Oncol 7(1):79–87
Drachtman RA, Cole PD, Golden CB, James SJ, Melnyk S, Aisner J, Kamen BA (2002) Dextromethorphan is effective in the treatment of subacute methotrexate neurotoxicity. Pediatr Hematol Oncol 5:319–327
Bernini JC, Fort DW, Griener JC, Kane BJ, Chappell WB, Kamen BA (1995) Aminophylline for methotrexate-induced neurotoxicity. Lancet 345 (8949):544–547
Resar LM, Phillips PC, Kastan MB, Leventhal BG, Bowman PW, Civin CI (1993) Acute neurotoxicity after intrathecal cytosine arabinoside in two adolescents with acute lymphoblastic leukemia of B-cell type. Cancer 71:117–123
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Kinirons, P., Fortune, A., Enright, H. et al. Acute pseudobulbar palsy due to methotrexate with rapid response to intravenous immunoglobulin. J Neurol 252, 1401–1403 (2005). https://doi.org/10.1007/s00415-005-0836-6
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DOI: https://doi.org/10.1007/s00415-005-0836-6