Genetic diversity of 17 autosomal STR loci in Meizhou Hakka population

Abstract

The genetic polymorphism of 17 autosomal short tandem repeat (STR) loci included in the PowerPlex® 18D System was evaluated from 638 unrelated healthy Han individuals of Meizhou in Guangdong Province, Southern China. The values of combined power of discrimination (CPD) and the combined probability of exclusion (CPE) were observed as 0.999999999999999 and 0.999999933. Penta E showed the highest values of polymorphism information content (0.9073), expected heterozygosity (0.9147), and observed heterozygosity (0.9373), whereas TPOX showed the lowest (0.5373, 0.6035, and 0.6082). Furthermore, both of the PCA plot and neighbor-joining phylogenetic tree showed that the Meizhou Hakka population has a relatively close genetic relationship with the Guangdong Han population. The results showed that most of these 17 autosomal STR loci were highly informative and can be effective for forensic individual identification and paternity testing in Meizhou Hakka population.

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Acknowledgments

The authors are very grateful to all sample donors for their contributions to this work and all those who helped with sample collection.

Funding

This study was funded by the National Natural Science Foundation of China (81971798) and the Natural Science Foundation of Guangdong Province (2019A15150).

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Correspondence to Hongyu Sun or Chao Liu.

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Informed consents were obtained before sample collection.

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The authors declare that they have no conflict of interest.

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Han, X., Shen, A., Yao, T. et al. Genetic diversity of 17 autosomal STR loci in Meizhou Hakka population. Int J Legal Med 135, 443–444 (2021). https://doi.org/10.1007/s00414-020-02253-9

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Keywords

  • Forensic genetics
  • Genetic polymorphism
  • Meizhou Hakka
  • STR