International Journal of Legal Medicine

, Volume 122, Issue 5, pp 367–372 | Cite as

Reduced CAG repeats length in androgen receptor gene is associated with violent criminal behavior

  • Singh Rajender
  • Guguluth Pandu
  • J. D. Sharma
  • K. P. C. Gandhi
  • Lalji Singh
  • Kumarasamy Thangaraj
Original Article

Abstract

Androgens mediate their functions through androgen receptors (AR). The two triplet repeats in the AR gene (CAG and GGN) are highly polymorphic among various populations and have been extensively studied in diverse clinical conditions and antisocial personality disorders. Several studies have reported either higher levels of testosterone among rapists or the correlation of shorter CAG repeats with criminal activities. However, to date, no study has analyzed AR gene in rapists worldwide, and no study has been conducted on criminals from Indian subcontinent. Therefore, we have analyzed the AR-CAG repeat length in 645 men, of which 241 were convicted for rape, 107 for murder, 26 for both murder and rape, and 271 were control males. The aim was to explore if there was any correlation between CAG repeat length and criminal behavior. The study revealed significantly shorter CAG repeats in the rapists (mean 18.44 repeats) and murderers (mean 17.59 repeats) compared to the control men (mean 21.19 repeats). The criminals who committed murder after rape had a far shorter mean repeat length (mean 17.31 repeats) in comparison to the controls or those convicted of rape or murder alone. In short, our study suggests that the reduced CAG repeats in the AR gene are associated with criminal behavior. This, along with other studies, would help in understanding the biological factors associated with the antisocial or criminal activities.

Keywords

Androgen receptor CAG repeat Rapists Murdered Antisocial activities Criminal activities 

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Singh Rajender
    • 1
    • 4
  • Guguluth Pandu
    • 2
  • J. D. Sharma
    • 3
  • K. P. C. Gandhi
    • 2
  • Lalji Singh
    • 1
  • Kumarasamy Thangaraj
    • 1
  1. 1.Centre for Cellular and Molecular BiologyHyderabadIndia
  2. 2.Andhra Pradesh State Forensic Science LaboratoryHyderabadIndia
  3. 3.Dr. HariSingh Gour VishwavidalyaMadhya PradeshIndia
  4. 4.Endocrinology DivisionCentral Drug Research InstituteLucknowIndia

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